Coordinate and Non-Coordinate Regulation of Histone mRNAs during Myoblast Growth and Differentiation
The fusion of myoblasts to produce non-dividing syncytial myotubes marks the end of cell proliferation during muscle cell differentiation. Following the signal to differentiate myoblasts enter G1 phase, retire from the cell cycle and differentiate into myotubes (3,4). The synthesis of muscle specific proteins is initiated as the cells begin to differentiate and defines the onset of the differentiated state (2,7). However the conditions necessary and sufficient to allow a proliferating population of cells to withdraw from the cell cycle and to switch from a growth specific to a differentiation specific program of gene expression have yet to be defined.
KeywordsPolyacrylamide Stein Thymidine Hydroxyurea Actinomycin
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