Growth Activation in Adult Rat Hepatocytes
The hepatocytes in normal adult rats are in a state of quiescence, or G0. They retain the capacity to proliferate, however, and re-enter the cell cycle in partial synchrony, responding vigorously to 2/3 hepatectomy and slightly less so to manipulations of the diet, administration of hormones, growth factors, toxic agents, and other substances. The precise physiological signals that regulate this growth remain elusive, but evidence from a number of laboratories indicates that blood-borne substances are responsible (1).
KeywordsInferior Vena Caval Liver Regeneration Hepatocyte Culture Partial Synchrony Elsevier Biomedical
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- 1.Bucher, N.L.R., McGowan, J.A. and Russell, W.E. 1983. Control of liver regeneration: present status. In Nerve, Organ and Tissue Regeneration: Research Perspectives. F.J. Seil, editor. Academic Press, New York, 455–469.Google Scholar
- 3.Bissell, D.M. 1983. Hepatocellular function in culture: The role of cell-cell-interaction. In Isolation, Characterization and Use of Hepatocytes. R.A. Harris and N.W. Cornell, editors. Elsevier Biomedical, New York. 51–59.Google Scholar
- 4.Hasegawa, K. and Koga, M. 1981. A high concentration of pyruvate is essential for survival of DNA synthesis in primary cultures of adult rat hepatocytes in a serum-free medium. Biomed. Res. 2: 217–221.Google Scholar
- 6.McGowan, J.A. and Bucher, N.L.R. 1983. Hepatotropic activity of pyruvate. In Isolation, Characterization and Uses of Hepatocytes, R.A. Harris and N.W. Cornell, editors. Elsevier Biomedical, New York. 165–170.Google Scholar