Products of the Major Histocompatibility Complex on Tumor Cells

  • Gerald N. Callahan
Part of the Contemporary Biomedicine book series (CB, volume 6)


The major histocompatibility complex (MHC) was originally defined as that region of murine genome that contained the genes that determined the fate of allografts (Gorer, 1938 and Gorer et al., 1948). A similar complex has since been identified in all mammalian species investigated. In addition, it is now known that the MHC contains a variety of genes whose products are intimately involved in the development and culmination of most, if not all, immune responses.


Major Histocompatibility Complex Antigen Expression Embryonal Carcinoma Cell Major Histocompatibility Complex Antigen Human Major Histocompatibility Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Arden, B., E. K. Wakeland, and J. Klein (1982), Immunogenetics 16, 491. Artz, K. and F. Jacob (1974), Transplantation 17, 632.Google Scholar
  2. Barclay, A. N. and D. W. Mason (1982), J. Exp. Med. 156, 1665.PubMedCrossRefGoogle Scholar
  3. Basham, T. Y., M. F. Bourgeade, A. A. Creasy, and T. C. Merigan (1982), Proc. Natl. Acad. Sci. USA 79, 3265.PubMedCrossRefGoogle Scholar
  4. Beller, D. I. and E. R. Unanue (1981), J. Immunol. 126, 263.PubMedGoogle Scholar
  5. Beller, D. I. and E. R. Unanue (1982), J. Immunol. 129, 971.PubMedGoogle Scholar
  6. Beller, D. I., J. Kiely, and E. R. Unanue (1980), J. Immunology 124, 1426.Google Scholar
  7. Benoist, C. O., D. J. Mathis, M. R. Kanter, V. E. Williams, and H. O. McDevitt (1983), Cell 34, 169.PubMedCrossRefGoogle Scholar
  8. Bernards, R., P. I. Schrier, A. Houweling, J. L. Bos, A. J. van der Erb, M. Zijlstra, and C. J. Melief (1983), Nature 305, 776.PubMedCrossRefGoogle Scholar
  9. Biddison, W. E., D. D. Kotsyu, J. L. Strominger, and M. S. Krangel (1982), J. Immunol. 129, 730.Google Scholar
  10. Brickell, P. M., D. S. Latchman, D. Murphy, K. Willison, and P. J. Rigby (1983), Nature 306, 756.PubMedCrossRefGoogle Scholar
  11. Calamai, E. G., D. I. Beller, and E. R. Unanue (1982), J. Immunol. 128, 1692.PubMedGoogle Scholar
  12. Calamai, E. G., D. I. Beller, and E. R. Unanue (1982), J. Immunol. 128, 1692.PubMedGoogle Scholar
  13. Callahan, G. N. and J. P. Allison (1978), Nature 271, 165.PubMedCrossRefGoogle Scholar
  14. Callahan, G. N. and R. E. Ferrell (1984), submitted.Google Scholar
  15. Callahan, G. N., M. A. Pellegrino, R. P. McCabe, L. Frugis, J. P. Allison, and S. Ferrone (1978), Behring Inst. Mitt. 62, 115.Google Scholar
  16. Callahan, G. N., L. E. Walker, and W. J. Martin (1981), Immunogenetics 12, 561.PubMedCrossRefGoogle Scholar
  17. Callahan, G. N., W. J. Martin, and D. Pardi (1982), J. Immunol. 128, 2116.PubMedGoogle Scholar
  18. Callahan, G. N., D. Pardi, M. A. Giedlin, J. P. Allison, D. M. Morizot, and W. J. Martin (1983), J. Immunol. 130, 471.PubMedGoogle Scholar
  19. Castro, J. E., R. Hunt, E. M. Lance, and P. B. Medawar (1974), Cancer Res. 34, 2055.PubMedGoogle Scholar
  20. Chapdelaine, J. M., T. V. Rajan, S. G. Nathenson, and F. Lilly (1981), Immunogenetics 14, 429.PubMedCrossRefGoogle Scholar
  21. Claas, F. H. J. and G. van Steenbrugge (1983), Tissue Antigens 21, 227.PubMedCrossRefGoogle Scholar
  22. Clarke, M. F., E. P. Gelmann, and M. S. Reitz (1983), Nature 305, 60.PubMedCrossRefGoogle Scholar
  23. Coligan, J. E., T. J. Kindt, H. Uehara, J. Martinko, and S. G. Nathenson (1981), Nature 291, 35.PubMedCrossRefGoogle Scholar
  24. Daar, A. S., S. V. Fuggle, A. Ting, and J. W. Fabre (1982), J. Immunol. 129, 447.PubMedGoogle Scholar
  25. Daynes, R. A., M. Emam, G. G. Kruger, and L. K. Roberts (1983), J. Immunol. 130, 1536.PubMedGoogle Scholar
  26. DeFreitas, E. C., R. W. Chestnut, H. M. Grey, and J. M. Chiller (1983), J. Immunol. 131, 23.PubMedGoogle Scholar
  27. de Waal, R. M. W., M. J. J. Bogman, C. N. Maas, and R. A. P. Koene (1983), Nature 303, 426.PubMedCrossRefGoogle Scholar
  28. Edidin, M., L. R. Gooding, and M. Johnson (1974), in Immunological Approaches to Fertility Control, ed., E. Diezfalusz, Karoboska Institute, Stockholm.Google Scholar
  29. Evans, G. A., D. H. Margulies, R. D. Camerini-Otero, K. Ozato, and J. G. Seidman (1982), Proc. Natl. Acad. Sci. USA 79, 1994.PubMedCrossRefGoogle Scholar
  30. Fellous, M., U. Nir, D. Wallach, G. Merlin, M. Rubenstein, and M. Revel (1982), Proc. Natl. Acad. Sci. USA 79, 3082.PubMedCrossRefGoogle Scholar
  31. Forman, J. (1980), in Cancer Markers: Diagnostic and Developmental Significance, ed., S. Sell, The Humana Press, Clifton, New Jersey.Google Scholar
  32. Gorer, P. A. (1938), J. Pathol. Bacteriol. 47, 231.CrossRefGoogle Scholar
  33. Gorer, P. A., S. Lyman, and G. D. Snell (1948), Proc. R. Soc. London 135, 449.CrossRefGoogle Scholar
  34. Haywood, G. R. and C. F. McKhann (1971), J. Exp. Med. 133, 1171.PubMedCrossRefGoogle Scholar
  35. Hellstrom, K. E. and I. Hellstrom (1969), Adv. Cancer Res. 12, 167.PubMedCrossRefGoogle Scholar
  36. Herberman, R. B. (ed.) (1980), in Natural Cell-Mediated Immunity Against Tu-mors, Academic Press Inc., New York.Google Scholar
  37. Hood, L., M. Steinmetz, and B. Malissen (1983), Ann. Rev. Immunol. 1, 529.Google Scholar
  38. Imamura, M., T. G. Gipson, N. Bensky, R. Justice, and W. J. Martin (1979), J. Immunol. 122, 1863.PubMedGoogle Scholar
  39. Kaufman, J. F., C. Auffray, A. J. Kornman, D. A. Shackleford, and J. Strominger (1984), Cell 36, 1.PubMedCrossRefGoogle Scholar
  40. Kindt, T. J. and M. A. Robinson (1984), in Fundamental Immunology, ed., W. E. Paul, Raven Press, New York.Google Scholar
  41. King, D. and P. P. Jones (1983), J. Immunol. 131, 315.PubMedGoogle Scholar
  42. Klein, J. (1979), Science 203, 516.PubMedCrossRefGoogle Scholar
  43. Klein, J. (1982), in Immunology, The Science of Self-Nonself Discrimination, John Wiley and Sons, New York.Google Scholar
  44. Klein, J., A. Juretic, C. M. Baxevanis, and Z. A. Nagy (1981), Nature 291, 455.PubMedCrossRefGoogle Scholar
  45. Klein, J., F. Figueroa, and Z. A. Nagy (1983), Ann. Rev. Immunol. 1, 119.CrossRefGoogle Scholar
  46. Lalanne, J. L., F. Bregegere, C. Delarbre, J. P. Abastado, G. Gachelin, P. Kourilsky (1982), Nucleic Acid Res. 10, 1039.PubMedCrossRefGoogle Scholar
  47. Lampson, L. A., C. P. Fisher, and J. P. Whelan (1983), J. Immunol. 130, 2471.PubMedGoogle Scholar
  48. Larhammar, D., U. Hammerling, M. Denaro, T. Lund, and R. A. Flavell (1983), Cell 134, 179.CrossRefGoogle Scholar
  49. Maloy, W. L., and J. E. Coligan (1982), Immunogenetics 16, 11.PubMedCrossRefGoogle Scholar
  50. Malissen, M., B. Malissen, and B. R. Jordan (1982), Proc. Natl. Acad. Sci. USA 79, 893.PubMedCrossRefGoogle Scholar
  51. Mann, D. L., M. Popovic, P. Sarin, C. Murray, M. S. Reitz, D. M. Strong, B.F. Haynes, R. C. Gallo, and W. A. Blatner (1983), Nature 305, 58.PubMedCrossRefGoogle Scholar
  52. Martin, W. J., T. G. Gipson, and J. M. Rice (1977), Nature 265, 738.PubMedCrossRefGoogle Scholar
  53. Mathis, D. J., C. O. Benoist, V. E. Williams, M. R. Kanter, and H. O. McDevitt (1983), Cell 32, 745.PubMedCrossRefGoogle Scholar
  54. Medawar, P. (1974), Cancer Res. 34, 2053.PubMedGoogle Scholar
  55. Medawar, P. B. and R. Hunt (1978), Nature 271, 164.PubMedCrossRefGoogle Scholar
  56. Mellor, A. L., E. H. Weiss, K. Ramachandran, and R. A. Flavell (1983), Nature 306, 792.PubMedCrossRefGoogle Scholar
  57. Morello, D., F. Daniel, P. Baldacci, Y. Cayre, G. Gachelin, and M. Kourilsky (1982), Nature 196, 260.CrossRefGoogle Scholar
  58. Newman, A. and M. F. Graves (1982), Clin. Exp. Immunol. 50, 41.PubMedGoogle Scholar
  59. Ostrand-Rosenberg, S. and A. Cohn (1981), Proc. Natl. Acad. Sci. USA, 78, 7106.PubMedCrossRefGoogle Scholar
  60. Ostrand-Rosenberg, S., A. L. Cohn, and J. W. Sandoz (1983), J. Immunol. 130, 1969.Google Scholar
  61. Owerbach, D., A. Lernmark, P. Platz, L. P. Ryder, L. Rask, P. A. Peterson, and K. Ludvigsson (1983), Nature 303, 815.PubMedCrossRefGoogle Scholar
  62. Parmiani, G., G. Carbone, G. Invernizzi, M. A. Pierotti, M. L. Sensi, M. J. Rogers, and E. Appella (1979), Immunogenetics 9, 1.CrossRefGoogle Scholar
  63. Plata, F., A. F. Tilkin, J. P. Levy, and F. Lilly (1981), J. Exp. Med. 154, 1795.PubMedCrossRefGoogle Scholar
  64. Robinson, P. J., K. Sege, P. Altevogt, P. A. Peterson, L. Lundin, F. Garrido, and V. Schininacher (1981), Immunogenetics 13, 261.PubMedCrossRefGoogle Scholar
  65. Rogers, M. J., L. R. Gooding, D. H. Marguiles, and G. A. Evans (1983), J. Immunol. 130, 2418.PubMedGoogle Scholar
  66. Sachs, D. (1984), in Fundamental Immunology, ed., W. E. Paul, Raven Press, New York.Google Scholar
  67. Scher, M. G., D. I. Beller, and E. R. Unanue (1980), J. Exp. Med. 152, 1684.PubMedCrossRefGoogle Scholar
  68. Schmidt, W., G. Atfield, and H. Festenstein (1979), Immunogenetics 8, 311.CrossRefGoogle Scholar
  69. Schmidt, W., L. Leben, G. Atfield, and H. Festenstein (1981), Immunogenetics 14, 323.PubMedCrossRefGoogle Scholar
  70. Schrier, P. I., R. Bernards, R. T. M. J. Vaessen, A. Houweling, and A. J. van der Eb (1983), Nature 305, 771.PubMedCrossRefGoogle Scholar
  71. Schwartz, R. H. (1984) in Fundamental Immunology, ed., W. E. Paul, Raven Press, New York.Google Scholar
  72. Shedlovsky, A., L. J. Clipson, J. C. Vandeberg, and W. F. Dove (1981), Immunogenetics 13, 413.PubMedCrossRefGoogle Scholar
  73. Sikora, K., P. Stern, and E. Lennox (1977), Nature 269, 813.PubMedCrossRefGoogle Scholar
  74. Steeg, P. S., R. N. Moore, H. M. Johnson, and J. J. Oppenheim (1980), J. Exp. Med. 152, 1734.PubMedCrossRefGoogle Scholar
  75. Steinman, R. M., N. Nogueira, M. D. Witmer, J. D. Tydings, and I. S. Mellman (1980), J. Exp. Med. 152, 1248.PubMedCrossRefGoogle Scholar
  76. Steinmetz, M., K. W. Moore, J. G. Frelinger, B. T. Sher, F.-W. Shen, E. A. Boyse, and L. Hood (1981), Cell 25, 683.PubMedCrossRefGoogle Scholar
  77. Stern, P. L. M. Gidlund, A. Orn, H. Wigzell (1980), Nature 285 341.PubMedCrossRefGoogle Scholar
  78. Strominger, J. L., H. T. Orr, P. Parham, H. L. Ploegh, D. L. Mann, H.Bilofsky, H. A. Saroff, T. T. Wu, and E. A. Kabat (1980), Scand. J. Immunol. 11, 573.PubMedCrossRefGoogle Scholar
  79. Testorelli, C., O. Marelli, W. Schmidt, and H. Festenstein (1980), J. Immunogenetics 7, 19.CrossRefGoogle Scholar
  80. Walker, E. B., L. L. Lanier, and N. L. Warner (1982), J. Exp. Med. 155, 629.PubMedCrossRefGoogle Scholar
  81. Weiss, E. H., A. Mellor, L. Golden, K. Fahrner, E. Simpson, J. Hurst, and R. A. Flavell (1983), Nature 301, 671.PubMedCrossRefGoogle Scholar
  82. Wong, G., I. Clark-Lewis, J. L. McKimm-Breschkin, A. W. Harris, and J. M. Schrader (1983), J. Immunol. 131, 788.Google Scholar
  83. Zinkernagel, R. M. and P. C. Doherty (1980), Adv. Immunol. 27, 251.Google Scholar

Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • Gerald N. Callahan
    • 1
  1. 1.Department of PathologyColorado State UniversityFort CollinsUSA

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