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Mechanisms of Smooth Muscle Relaxation

  • Chapter
Calcium and Contractility

Part of the book series: Contemporary Biomedicine ((CB,volume 5))

Abstract

Normally, contractions of smooth muscle, which follow activation of the ATPase properties of myosin by phosphorylation in the presence of calmodulin and Ca (Chapter 2), are terminated by withdrawal of the initiating stimulus followed by a fall in the free cytoplasmic Ca concentration, mediated by the physiological systems that usually maintain the cation at a low level. Relaxation (or inhibition of contraction) in the presence of a contractile stimulus, can be achieved by a reduction in free cytoplasmic Ca levels or by reducing the rate of myosin phosphorylation in the presence of Ca-calmodulin through phosphorylation of myosin light chain kinase by a cyclic AMP-dependent phosphokinase (Chapter 2).

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  1. T. Godfraind
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  1. McMaster University, Hamilton, Ontario, Canada

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Godfraind, T., Miller, R.C. (1985). Mechanisms of Smooth Muscle Relaxation. In: Grover, A.K., Daniel, E.E. (eds) Calcium and Contractility. Contemporary Biomedicine, vol 5. Humana Press. https://doi.org/10.1007/978-1-4612-5172-9_4

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  • DOI: https://doi.org/10.1007/978-1-4612-5172-9_4

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