Mechanisms of Hereditary Visual Cell Disease

  • Gerald J. Chader
  • Gustavo Aguirre
  • Somes Sanyal
  • Gregory Acland
  • Lawrence Stramm
Part of the Cell and Developmental Biology of the Eye book series (EYE)

Abstract

Hereditary and developmental diseases of the photoreceptorpigment epithelium complex account for a significant percentage of blindness in young adults. Over 100,000 people demonstrate some form of visual impairment in the USA as a result of these diseases; up to 2% of the population carry the gene(s) for these disorders even though they themselves enjoy normal vision (Boughman et al., 1980). In the human, the term Retinitis Pigmentosa (RP) has been applied to the family of such hereditary diseases which causes degeneration of the photoreceptor cells and subsequent degeneration of other retinal cell types. Several distinct genetic classes of this condition are now known with differing times of onset, levels of severity and clinical courses. It thus seems clear that RP is a family of allied diseases of different etiologies whose final common pathway leads to retinal malfunction and blindness.

Keywords

Hydrolysis Retina Neurol Stein Cataract 

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Copyright information

© Springer-Verlag New York Inc. 1985

Authors and Affiliations

  • Gerald J. Chader
  • Gustavo Aguirre
  • Somes Sanyal
  • Gregory Acland
  • Lawrence Stramm

There are no affiliations available

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