Skip to main content

A Progress Report on Neurochemical and Neuroendocrine Regulation in Normal and Pathologic Aging

  • Conference paper
Aging 2000: Our Health Care Destiny
  • 63 Accesses

Summary

Recent findings from this lab include the progressive decrease during normal human aging of caudate D2 receptors and cortical S2 receptors. Also, the ovary-dependent neuroendocrine aging syndrome of female rodents is described.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aschheim, P.: Resultats fournis per la greffe hererochrone des ovarie dans l’ etude de la regulation hypothalamus-hypophyso-ovariene de la ratte senile. Gerontologia 10, 65–67 (1965).

    Article  CAS  Google Scholar 

  • Blake, C.A., Elias, K.A., and Hoffman, L.J.: Ovariectomy of young adult rats has a sparing effect on the suppressed ability of aged rats to release luteinizing hormone. Biol. Repro. 28, 575–585 (1983).

    Article  CAS  Google Scholar 

  • Blatt, C., Mileham, K., Haas, M., Nesbitt, M.N., Harper, M.E., and Simon, M.I.: Chromosome mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse. Proc. Nat. Acad. Sci. 80, 6298–6302 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Brawer, J.R., Naftolin, R., Martin, J., and Sonnenschein, C.: Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat. Endocrinology 103, 510–512 (1978).

    Article  Google Scholar 

  • Brawer, J.R., and Sonnenschein, C.: Cytopathological effects of estradiol on the arcuate nucleus of the female rat. A possible mechanism for pituitary tumorigenesis. Am. J. Anat. 144, 157–187 (1975).

    Article  Google Scholar 

  • Bridges, T.P., Cannon, H.E., and Wyatt, R.J.: Burned-out schizophrenia: evidence for age effects in schizophrenia symptomatology. J. Gerontology 33, 835–839 (1978).

    Google Scholar 

  • Bugiani, C., Salvariani, S., Perdelli, F., Mancardi, G.L., and Leonardi, A.: Nerve cell loss with aging in the putamen. Eur. Neurol. 17, 286–291 (1978).

    Article  PubMed  CAS  Google Scholar 

  • Casanueva, F., Cocchi, D., Locatelli, V., Flauto, C., Zambotti, F., Bestetti, G., Rossi, G.L., and Muller, E.: Defective central nervous system dopaminergic function in rats with estrogen-induced pituitary tumors, as assessed by plasma prolactin concentrations. Endocrinology 110, 590–599 (1982).

    Article  PubMed  CAS  Google Scholar 

  • Coyle, J.T., and Schwarcz, R.: Lesion of striatal neurons with kainic acid provides a model for Huntington’s chorea. Nature 263, 244–246 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Felicio, L.S., Nelson, J.F., Gosden, R.G., and Finch, C.E.: Restoration of ovulatory cycles by young ovarian grafts in aging mice: potentiation by long-term ovariectomy decreases with age. Proc. Nat. Acad. Sci. 80, 6076–6080 (1983).

    Article  PubMed  CAS  Google Scholar 

  • Finch, C.E.: Relationships of aging changes in the basal ganglia to manifestations of Huntington’s chorea. Ann. Neurol. 7, 406–411 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Finch, C.E., Felicio, L.S., Flurkey, K., Gee, D.M., Mobbs, C., Nelson, J.F., and Osterburg, H.H.: Studies in ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice. Peptides, 1, Suppl. 1, 163–176 (1980).

    Google Scholar 

  • Finch, C.E., Felicio, L.S., Flurkey, K., Gee, D.M., Mobbs, C., Nelson, J.F., and Osterburg, H.H.: Studies in ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice. Peptides, 1, Suppl. 1, 163–176 (1980).

    Google Scholar 

  • Finch, C.E., and Mobbs, C.V.: Hormonal influences on hypothalamic sensitivity during aging in female rodents. In Meites, J. (Ed.), Neuroendocrinology of Aging, pp. 143–171. New York: Plenum, 1983.

    Google Scholar 

  • Gee, D.M., Flurkey, K., and Finch, C.E.: Aging and the regulation of luteinizing hormone in C57BL/6J mice: Impaired elevations after ovariectomy and spontaneous elevations at advanced ages. Biol. Repro. 28, 598–607 (1983).

    Article  CAS  Google Scholar 

  • Gee, D.M., Flurkey, K., and Finch, C.E.: The regulation of the LH surge by estradiol in ovariectomized C57BL/6J mice. Effects of estradiol implant size, postovariectomy duration and aging. Endocrinology 114, 685–693 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Gosden, R.G., Liang, S.C., Felicio, L.S, Nelson, J.F., and Finch, C.E.: Imminent oocyte exhaustion and reduced follicular recruitment mark the climacteric in aging mice. Biol. Repro. 28, 255–260 (1983).

    Article  CAS  Google Scholar 

  • Guyton, A.C.: Textbook of Medical Physiology, 6th ed, p. 1016. Philadelphia: Saunders, 1981.

    Google Scholar 

  • Kawashima, S.: Influence of continued injections of sex steroids on the estrous cycle in the adult rat. Annot. Zool. Japan 33, 226–232 (1960).

    Google Scholar 

  • Kryter, K.: The effects of noise on man. New York: Academic, 1970.

    Google Scholar 

  • MacLusky, N.J., and Naftolin, F.: Sexual differentiation of the central nervous system. Science 211, 1294–1303 (1981).

    Article  PubMed  CAS  Google Scholar 

  • MacLusky, N.J., and Naftolin, F.: Sexual differentiation of the central nervous system. Science 211, 1294–1303 (1981).

    Article  PubMed  CAS  Google Scholar 

  • Mason, S.T., and Fibiger, H.C.: Kainic acid lesions of the striatum in rats mimic the spontaneous motor abnormalities of Huntington’s disease. Neuropharmacology 18, 403–407 (1979).

    Article  PubMed  CAS  Google Scholar 

  • McGeer, P.L., McGeer, E.G., and Suzuki, J.S.: Aging and extrapyramidal function. Arch. Neurol. (Chicago) 34, 33–35 (1977).

    CAS  Google Scholar 

  • Mobbs, C.V., Flurkey, K., Gee, D.M., Yamamoto, K., Sinha, Y.N., and Finch, C.E.: Estradiol-induced anovulatory syndrome in female C57BL/6J mice: age-like neuroendocrine, but not ovarian impairments. Biol. Repro. 30, 556–563 (1984a).

    Article  CAS  Google Scholar 

  • Mobbs, C.V., Flurkey, K., Gee, D.M., Yamamoto, K., Sinha, Y.N., and Finch, C.E.: Estradiol-induced anovulatory syndrome in female C57BL/6J mice: age-like neuroendocrine, but not ovarian impairments. Biol. Repro. 30, 556–563 (1984a).

    Article  CAS  Google Scholar 

  • Morgan, D.M., Marcusson, J.O., and Finch, C.E.: Contamination of serotonin-2 binding sites by an alpha-1 adrenergic component in assays with (3H)spiperone. Life Sci. 34, 2507–2514 (1984).

    Article  PubMed  CAS  Google Scholar 

  • Nelson, J.F., Felicio, L.S., Sinha, Y.N., and Finch, C.E.: An ovarian role in the spontaneous pituitary tumorigenesis and hyperprolactinemia of aging female mice. The Gerontologist 20 Part II (Abstract), 171 (1980).

    Google Scholar 

  • Rosen, S., Bergman, M., Plester, D., El-Mofty, A., and Satti, M.H.: Presbycusis study of a relatively noise-free population in the Sudan. Ann. Otol. Rhinol. Laryngol. 71, 727–743 (1962).

    PubMed  CAS  Google Scholar 

  • Schipper, H., Brawer, J.R., Nelson, J.F., Felicio, L.S., and Finch, C.E.: The role of the gonads in the histologic aging of the hypothalamic arcuate nucleus. Biol. Repro. 25, 413–419 (1981).

    Article  CAS  Google Scholar 

  • Seide, H., and Mtiller, H.: Choreiform movements as side effects of phenothiazine medication in geriatric patients. J. Am. Ger. Soc. 15, 517–522 (1977).

    Google Scholar 

  • Severson, J.A., and Finch, C.E.: Reduced dopaminergic binding with aging in the rodent striatum. Brain Res. 192, 147–162 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Smith, J.M., and Baldessarini, R.J.: Changes in prevalence, severity and recovery in tardive dyskinesia with age. Arch. Gen. Psychiat. 37, 1368–1373 (1980).

    PubMed  CAS  Google Scholar 

  • Talbert, G.: Aging of the female reproductive system. In Finch, C.E., Hayflick, L. (Eds.), Handbook of the Biology of Aging, pp. 318–356. New York: Van Nostrand, 1977.

    Google Scholar 

  • vom Saal, F.S., and Bronson, F.H.: In utero proximity of female mouse fetuses to males: effect on reproductive performance during later life. Biol. Repro. 19, 842–853 (1978).

    Article  Google Scholar 

  • vom Saal, F.S., and Bronson, F.H.: In utero proximity of female mouse fetuses to males: effect on reproductive performance during later life. Biol. Repro. 19, 842–853 (1978).

    Article  Google Scholar 

  • Wise, P.M.: Aging of the female reproductive system. Rev. Biol. Res. Aging 1, 195–222 (1983).

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag New York Inc.

About this paper

Cite this paper

Finch, C.E. (1985). A Progress Report on Neurochemical and Neuroendocrine Regulation in Normal and Pathologic Aging. In: Gaitz, C.M., Samorajski, T. (eds) Aging 2000: Our Health Care Destiny. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5058-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-5058-6_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9544-0

  • Online ISBN: 978-1-4612-5058-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics