Summary
Recent findings from this lab include the progressive decrease during normal human aging of caudate D2 receptors and cortical S2 receptors. Also, the ovary-dependent neuroendocrine aging syndrome of female rodents is described.
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References
Aschheim, P.: Resultats fournis per la greffe hererochrone des ovarie dans l’ etude de la regulation hypothalamus-hypophyso-ovariene de la ratte senile. Gerontologia 10, 65–67 (1965).
Blake, C.A., Elias, K.A., and Hoffman, L.J.: Ovariectomy of young adult rats has a sparing effect on the suppressed ability of aged rats to release luteinizing hormone. Biol. Repro. 28, 575–585 (1983).
Blatt, C., Mileham, K., Haas, M., Nesbitt, M.N., Harper, M.E., and Simon, M.I.: Chromosome mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse. Proc. Nat. Acad. Sci. 80, 6298–6302 (1983).
Brawer, J.R., Naftolin, R., Martin, J., and Sonnenschein, C.: Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat. Endocrinology 103, 510–512 (1978).
Brawer, J.R., and Sonnenschein, C.: Cytopathological effects of estradiol on the arcuate nucleus of the female rat. A possible mechanism for pituitary tumorigenesis. Am. J. Anat. 144, 157–187 (1975).
Bridges, T.P., Cannon, H.E., and Wyatt, R.J.: Burned-out schizophrenia: evidence for age effects in schizophrenia symptomatology. J. Gerontology 33, 835–839 (1978).
Bugiani, C., Salvariani, S., Perdelli, F., Mancardi, G.L., and Leonardi, A.: Nerve cell loss with aging in the putamen. Eur. Neurol. 17, 286–291 (1978).
Casanueva, F., Cocchi, D., Locatelli, V., Flauto, C., Zambotti, F., Bestetti, G., Rossi, G.L., and Muller, E.: Defective central nervous system dopaminergic function in rats with estrogen-induced pituitary tumors, as assessed by plasma prolactin concentrations. Endocrinology 110, 590–599 (1982).
Coyle, J.T., and Schwarcz, R.: Lesion of striatal neurons with kainic acid provides a model for Huntington’s chorea. Nature 263, 244–246 (1976).
Felicio, L.S., Nelson, J.F., Gosden, R.G., and Finch, C.E.: Restoration of ovulatory cycles by young ovarian grafts in aging mice: potentiation by long-term ovariectomy decreases with age. Proc. Nat. Acad. Sci. 80, 6076–6080 (1983).
Finch, C.E.: Relationships of aging changes in the basal ganglia to manifestations of Huntington’s chorea. Ann. Neurol. 7, 406–411 (1980).
Finch, C.E., Felicio, L.S., Flurkey, K., Gee, D.M., Mobbs, C., Nelson, J.F., and Osterburg, H.H.: Studies in ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice. Peptides, 1, Suppl. 1, 163–176 (1980).
Finch, C.E., Felicio, L.S., Flurkey, K., Gee, D.M., Mobbs, C., Nelson, J.F., and Osterburg, H.H.: Studies in ovarian-hypothalamic-pituitary interactions during reproductive aging in C57BL/6J mice. Peptides, 1, Suppl. 1, 163–176 (1980).
Finch, C.E., and Mobbs, C.V.: Hormonal influences on hypothalamic sensitivity during aging in female rodents. In Meites, J. (Ed.), Neuroendocrinology of Aging, pp. 143–171. New York: Plenum, 1983.
Gee, D.M., Flurkey, K., and Finch, C.E.: Aging and the regulation of luteinizing hormone in C57BL/6J mice: Impaired elevations after ovariectomy and spontaneous elevations at advanced ages. Biol. Repro. 28, 598–607 (1983).
Gee, D.M., Flurkey, K., and Finch, C.E.: The regulation of the LH surge by estradiol in ovariectomized C57BL/6J mice. Effects of estradiol implant size, postovariectomy duration and aging. Endocrinology 114, 685–693 (1984).
Gosden, R.G., Liang, S.C., Felicio, L.S, Nelson, J.F., and Finch, C.E.: Imminent oocyte exhaustion and reduced follicular recruitment mark the climacteric in aging mice. Biol. Repro. 28, 255–260 (1983).
Guyton, A.C.: Textbook of Medical Physiology, 6th ed, p. 1016. Philadelphia: Saunders, 1981.
Kawashima, S.: Influence of continued injections of sex steroids on the estrous cycle in the adult rat. Annot. Zool. Japan 33, 226–232 (1960).
Kryter, K.: The effects of noise on man. New York: Academic, 1970.
MacLusky, N.J., and Naftolin, F.: Sexual differentiation of the central nervous system. Science 211, 1294–1303 (1981).
MacLusky, N.J., and Naftolin, F.: Sexual differentiation of the central nervous system. Science 211, 1294–1303 (1981).
Mason, S.T., and Fibiger, H.C.: Kainic acid lesions of the striatum in rats mimic the spontaneous motor abnormalities of Huntington’s disease. Neuropharmacology 18, 403–407 (1979).
McGeer, P.L., McGeer, E.G., and Suzuki, J.S.: Aging and extrapyramidal function. Arch. Neurol. (Chicago) 34, 33–35 (1977).
Mobbs, C.V., Flurkey, K., Gee, D.M., Yamamoto, K., Sinha, Y.N., and Finch, C.E.: Estradiol-induced anovulatory syndrome in female C57BL/6J mice: age-like neuroendocrine, but not ovarian impairments. Biol. Repro. 30, 556–563 (1984a).
Mobbs, C.V., Flurkey, K., Gee, D.M., Yamamoto, K., Sinha, Y.N., and Finch, C.E.: Estradiol-induced anovulatory syndrome in female C57BL/6J mice: age-like neuroendocrine, but not ovarian impairments. Biol. Repro. 30, 556–563 (1984a).
Morgan, D.M., Marcusson, J.O., and Finch, C.E.: Contamination of serotonin-2 binding sites by an alpha-1 adrenergic component in assays with (3H)spiperone. Life Sci. 34, 2507–2514 (1984).
Nelson, J.F., Felicio, L.S., Sinha, Y.N., and Finch, C.E.: An ovarian role in the spontaneous pituitary tumorigenesis and hyperprolactinemia of aging female mice. The Gerontologist 20 Part II (Abstract), 171 (1980).
Rosen, S., Bergman, M., Plester, D., El-Mofty, A., and Satti, M.H.: Presbycusis study of a relatively noise-free population in the Sudan. Ann. Otol. Rhinol. Laryngol. 71, 727–743 (1962).
Schipper, H., Brawer, J.R., Nelson, J.F., Felicio, L.S., and Finch, C.E.: The role of the gonads in the histologic aging of the hypothalamic arcuate nucleus. Biol. Repro. 25, 413–419 (1981).
Seide, H., and Mtiller, H.: Choreiform movements as side effects of phenothiazine medication in geriatric patients. J. Am. Ger. Soc. 15, 517–522 (1977).
Severson, J.A., and Finch, C.E.: Reduced dopaminergic binding with aging in the rodent striatum. Brain Res. 192, 147–162 (1980).
Smith, J.M., and Baldessarini, R.J.: Changes in prevalence, severity and recovery in tardive dyskinesia with age. Arch. Gen. Psychiat. 37, 1368–1373 (1980).
Talbert, G.: Aging of the female reproductive system. In Finch, C.E., Hayflick, L. (Eds.), Handbook of the Biology of Aging, pp. 318–356. New York: Van Nostrand, 1977.
vom Saal, F.S., and Bronson, F.H.: In utero proximity of female mouse fetuses to males: effect on reproductive performance during later life. Biol. Repro. 19, 842–853 (1978).
vom Saal, F.S., and Bronson, F.H.: In utero proximity of female mouse fetuses to males: effect on reproductive performance during later life. Biol. Repro. 19, 842–853 (1978).
Wise, P.M.: Aging of the female reproductive system. Rev. Biol. Res. Aging 1, 195–222 (1983).
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Finch, C.E. (1985). A Progress Report on Neurochemical and Neuroendocrine Regulation in Normal and Pathologic Aging. In: Gaitz, C.M., Samorajski, T. (eds) Aging 2000: Our Health Care Destiny. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5058-6_6
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DOI: https://doi.org/10.1007/978-1-4612-5058-6_6
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