Noncortical Transmitter-Specific Neurons in Senile Dementia of the Alzheimer Type

  • William Bondareff
Conference paper

Summary

The benchmark of senile dementia of the Alzheimer type (SDAT) is an abundance of neuritic plaques and neurofibrillary tangles in the cerebral cortex. Noncortical neurons, some of which are associated with specific neurotransmitters, are also involved. The latter, including neurons of the nucleus locus ceruleus (noradrenergic), nucleus basalis complex (cholinergic), and nuclei of the brainstem raphe (serotonergic), innervate target regions in the cerebral cortex and selective noncortical regions of the brain known to be involved in “higher” cortical functions. Neuronal pathology in the noncortical noradrenergic and cholinergic nuclei appears to affect the cortical distributions of norepinephrine and acetylcholine and may also influence the distribution of plaques and tangles in target regions. These interrelationships between noncortical, transmitter-specific neurons and the target neurons they innervate are age related. Their clinical expression may contribute to the severity of symptoms in the early onset subtype of Alzheimer’s disease.

Keywords

Dopamine Dementia Serotonin Norepinephrine Neurol 

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Copyright information

© Springer-Verlag New York Inc. 1985

Authors and Affiliations

  • William Bondareff

There are no affiliations available

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