Murine T-Cell Receptor Genes and the Problems of Cellular Recognition and Repertoire Selection
The recent isolation of cDNA clones encoding the presumptive T-cell receptor molecules (as reviewed in references 1–4) has brought us within striking distance of elucidating the basic mechanism of T-cell recognition, that is the receptor-1igand interaction, and also should help to illuminate the role of the thymus in T-cell differentiation. The nature of the ligand itself is also being scrutinized in this volume by Schwartz, Bersofsky and others. This brief manuscript will attempt to summarize some of the things we know and don’t know about these issues and discuss some of the approaches that we have taken in trying to address them.
KeywordsStriking Distance Repertoire Selection Soluble Protein Expression Chain mRNA Expression Secondary Structure Homology
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