Disposition of Endogenous S-Adenosylhomocysteine and Homocysteine Following Exposure to Nucleoside Analogues and Methotrexate

  • P. M. Ueland
  • A. Svardal
  • H. Refsum.
  • J. R. Lillehaug
  • J-S. Schanche
  • S. Helland
Part of the Experimental Biology and Medicine book series (EBAM, volume 12)


S-Adenosylhomocysteine (AdoHcy) is a product from and an inhibitor of S-adenosylmethionine-dependent transmethylation reactions. This compound is degraded to adenosine and L-homocysteine (Hcy) in the cell through the action of the enzyme AdoHcy hydrolase (EC (de la Haba & Cantoni, 1959). The view is held that the AdoHcy hydrolase reaction is the only source of Hcy in vertebrates (Cantoni & Chiang, 1980). Hcy is converted to cystathionine or is salvaged to methionine. In all tissues, except liver and kidney, the latter pathway is catalyzed by a single enzyme, which requires 5-methyl -tetrahydrofolate as methyl donor (Mudd & Levy, 1983). These metabolic relations are depicted in figure 1.


Nucleoside Analogue Extracellular Medium Cl16 Cell Adenosine Analogue Transmethylation Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© The Humana Press Inc. 1986

Authors and Affiliations

  • P. M. Ueland
    • 1
  • A. Svardal
    • 1
  • H. Refsum.
    • 1
  • J. R. Lillehaug
    • 1
  • J-S. Schanche
    • 1
  • S. Helland
    • 1
  1. 1.Clinical Pharmacology Unit, Department of PharmacologyUniversity of BergenBergenNorway

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