In Vivo Discriminative Stimulus (CUE) Properties in Rats of Beta-Phenylethylamine
In recent years the drug discrimination (DD) bioassay has proved of value in analysing drug actions (Colpaert and Slangen, 1982). This procedure is a whole animal assay for analysis in vivo of actions of drugs and endogenous agents, thus it may be useful in analysing functions of endogenous trace amines. Colpaert et al. (1980) suggested that the cue properties of cocaine in the DD procedure are mediated by PEA, since the potencies of MAO inhibitors in generalising to cocaine depended on their relative potencies in inhibiting MAO Type B, for which PEA is a preferred substrate. Huang and Ho (1974) reported that rats discriminating amphetamine generalized to PEA after pretreatment with iproniazid. These data suggest that the cue properties of stimulant drugs may be mediated by endogenous PEA. We have therefore been involved in recent years with:- (I) Analysis of the actions of PEA as a “training” drug and, (II) Analysing PEA’s actions in animals discriminating the stimulant dl-cathinone.
KeywordsDrug Discrimination Generalization Test Stimulant Drug Partial Generalization Discriminative Stimulus Property
Unable to display preview. Download preview PDF.
- Blau, K. (1978) The significance of phenylethylamine in phenylketonuria and related disorders. In: Noncatecholic Phenylethylamines. Part 1 (Mosnaim A.D. and Wolf M.E., eds.) pp. 385–396, Marcel Dekker, New York.Google Scholar
- Colpaert F.C., Kuyps J.J.M.D., Niemegeers C.J.E. and Janssen P.A.J. (1976) Discriminative stimulus properties of a low dl-Amphetamine dose. Arch. int. Pharmacodyn. Therap. 223, 34–42.Google Scholar
- Colpaert F.C. and Slangen J.L. (1982) Drug Discrimination: Applications in C.N.S. Pharmacology Elsevier Biomedical Press, Amsterdam.Google Scholar
- Colpaert F.C. and Janssen, P.A.J. (1984) Agonist and antagonist effects of prototype opiate drugs in rats discriminating fentamyl from saline: Characteristics of partial generalization. J. Pharmac. exp. Therap. 230, 193–199.Google Scholar
- Goudie, A.J. (1982) Discriminative stimulus properties in an operant task of beta-phenylethylamine. In: Drug Discrimination: Applications in C.N.S. Pharmacology (Colpaert F.C. and Slangen J.L. eds.) pp. 165–180, Elsevier Biomedical Press, Amsterdam.Google Scholar
- Shannon H.E. and De Gregorio C.M. (1982) Self-administration of the endogenous trace amines B-phenylethylamine, N-Methyl Phenylethylamine and Phenylethanolamine in dogs. J. Pharmac. exp Therap. 222, 52–60Google Scholar