In Vivo Discriminative Stimulus (CUE) Properties in Rats of Beta-Phenylethylamine
In recent years the drug discrimination (DD) bioassay has proved of value in analysing drug actions (Colpaert and Slangen, 1982). This procedure is a whole animal assay for analysis in vivo of actions of drugs and endogenous agents, thus it may be useful in analysing functions of endogenous trace amines. Colpaert et al. (1980) suggested that the cue properties of cocaine in the DD procedure are mediated by PEA, since the potencies of MAO inhibitors in generalising to cocaine depended on their relative potencies in inhibiting MAO Type B, for which PEA is a preferred substrate. Huang and Ho (1974) reported that rats discriminating amphetamine generalized to PEA after pretreatment with iproniazid. These data suggest that the cue properties of stimulant drugs may be mediated by endogenous PEA. We have therefore been involved in recent years with:- (I) Analysis of the actions of PEA as a “training” drug and, (II) Analysing PEA’s actions in animals discriminating the stimulant dl-cathinone.
KeywordsDopamine Schizophrenia Cocaine Fentanyl Amphetamine
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