Abstract
Investigations in the neurochemical pathology of the dopamine (DA), noradrenaline (NA) and serotonin (5HT) systems in humans do not involve studies of functional parameters, as the high-affinity uptake and the stimulated release of the transmitters. This is probably based on the relative rapid decline of these parameters during postmortem storage in situ as well as their drastic decrease by tissue freezing in liquid nitrogen (LN, see below). As an alternative, binding studies were recently proposed as reliable probes for investigating the uptake complexes (see for example Davitch et al, 1984), but their specifity as well as their validity for the high-affinity uptake process is to be elucidated.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Haberland N., Hetey L., Hackensellner H.A., and Matthes G. (1984) Characterization of the synaptosomal dopamine uptake from rat and human brain tissue after low temperature preservation. Probl. Haematol. Transfsn. Transplantn. 11, 277–281.
Haberland N., and Hetey L. (1985) Characterization of the synaptosomal dopamine uptake in studies with postmortem human brain, in: Dopamine Systems and their Regulation (Woodruff G.N., ed.), Macmillan Press Ltd., London, in press.
Hetey L., Schwitzkowsky R., and Oelssner W. (1983) Influence of psychotomimetics and lisuride on synaptosomal dopamine release in the nc. accumbens of rats, Eur. J. Pharmacol. 93, 213–220.
Hetey L., Haberland N., and Schulze R. (1985) Effects of psychotomimetics and lisuride on synaptosomal tyrosine hydroxylase activity and dopamine uptake in the nc. accumbens of rats. Biogenic Amines 2, in press.
Iversen L.L., Reynolds G.P., and Snyder S.H. (1983) Pathophysiology of schizophrenia - causal role for dopamine or noradrenaline? Nature 305, 577–578.
Javitch, J.A., Blaustein R.O., and Snyder S.H. (1984) [−3H]Mazindol binding associated with neuronal dopamine and norepinephrine uptake sites. Mol. Pharmacol. 26, 35–44.
Mackay A.V.P., Iversen L.L., Rossor M., Spokes E., Bird E., Arregui A., Creese I., and Snyder S.H. (1982) Increased brain dopamine and dopamine receptors in schizophrenia. Arch. Gen. Psychiatry 39, 991–997.
Perry E.K. and Perry R.H. (1983) Human brain neurochemistry - some postmortem problems. Life Sciences 33, 1733–1743.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 The Humana Press Inc
About this chapter
Cite this chapter
Hetey, L., Haberland, N., Schwitzkowsky, R. (1985). Study of the Synaptosomal Catecholamine Uptake in Postmortem Brain of Schizophrenics. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_46
Download citation
DOI: https://doi.org/10.1007/978-1-4612-5010-4_46
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9397-2
Online ISBN: 978-1-4612-5010-4
eBook Packages: Springer Book Archive