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Abstract

In 6 healthy, young volunteers the kinetics of L-tryptophan (TRP) following 3 different single oral doses (1.5, 3, 6 g) simultaneously with urinary tryptamine (TA) excretion were examined. Blood and urine samples were collected hourly before and for 14 h after TRP. TRP in plasma and TA in urine were analysed by specific and sensitive HPLC methods using UV and fluorometric detection, respectively. The measurements were repeated in one volunteer after pretreatment with the decarboxylase inhibitor benserazide (3 × 125 mg/d for 15 days), and in 2 volunteers after pretreatment with the selective and reversible inhibitor of MAO-A, brofaremine (150 mg/d for 10 days).

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© 1985 The Human Press Inc.

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Wollmann, H., Nilsson, E., Antonin, K.H., Bieck, P.R. (1985). Tryptamine Kinetics in Human Volunteers. In: Boulton, A.A., Maitre, L., Bieck, P.R., Riederer, P. (eds) Neuropsychopharmacology of the Trace Amines. Humana Press. https://doi.org/10.1007/978-1-4612-5010-4_37

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  • DOI: https://doi.org/10.1007/978-1-4612-5010-4_37

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9397-2

  • Online ISBN: 978-1-4612-5010-4

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