β-Phenylethylamine and Amphetamine Compared in Tests of Anorexia and Place-Preference Conditioning
Adult, male non-deprived rats were accustomed to eating a highly-palatable diet in a 30 min period. Administration of β-phenylethylamine (PE) immediately before the feeding test produced a dose-related (3–30 mg/kg, i.p.) reduction in intake over the first 15 min. A significant anorectic effect was found following 10 and 30 mg/kg of PE. The effect of PE was short-lived, since over the complete 30 min, the reduction in the consumption of the diet was then considerably attenuated. Both d-and l-amphetamine (AMPH) produced dose-related anorectic effects in the same test, and 30 min intake was significantly reduced after 0.3 mg/kg d-AMPH and 1.0 mg/kg l-AMPH. Comparisons with other data show that the anorectic action of PE can be distinguished from its hypodipsic effect, its reinforcing effect as determined in the conditioned place-preference test, and from its ability to induce behavioural stereotypy. The data indicate, therefore, a relatively selective behavioural effect of PE to reduce the consumption of a palatable diet.
KeywordsPlace Preference Conditioning Conditioned Taste Aversion Anorectic Effect Trace Amine Palatable Diet
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- Boulton, A.A. and Juorio, A.V. (1982) Brain trace amines. In: Handbook of Neurochemistry, Vol.1 (Lajtha, A., ed), pp. 189–222. Plenum, New York.Google Scholar
- Dourish, C.T. (1984) Studies on the mechanism of action of β-phenylethylamine stereotypy in rodents: Implications for a β-phenylethylamine animal model of schizophrenia. In: Neurobiology of the Trace Amines (Boulton, A.A., Baker, G.B., Dewhurst, W.G. and Sandler, M., eds), pp. 389–411. Humana Press, Clifton NJ.Google Scholar
- Gilbert, D.B. and Cooper, S.J. (1985) Analysis of dopamine D1 and D2 receptor involvement in d-and 1-amphetamine-induced anorexia in rats. Brain Res. Bull. (in press).Google Scholar
- Nielsen, J.A., Chapin, D.S. and Moore, K.E. (1983) Differential effects of d-amphetamine, β-phenylethylamine, cocaine and methylphenidate on the rate of dopamine synthesis in terminals of nigrostriatal and mesolimbic neurons and on the efflux of dopamine metabolites into cerebroventricular perfusates of rats. Life Sci. 33: 1899–1907.PubMedCrossRefGoogle Scholar
- Robbins, T.W. and Sahakian, B.J. (1981) Behavioural and neurochemical determinants of drug-induced stereotypy. In: Metabolic Disorders of the Nervous System (Rose, F.C., ed), pp.224–291. Pitman, London.Google Scholar