Abstract
LAV or LAV related viruses were isolated from patients with AIDS or with lymphadenopathy. The results presented here indicate that four major components (p45, p25, pl8 and pl3) are detected in purified virions. The p25 and the pl3 are internal proteins of LAV since they cannot be easily iodinated in the virions. The p25 can be purified by phosphocellulose chromatography and the purified protein can be labelled with I. The pl8 is either a gag gene product or a transmembrane protein. The major core proteins p25 of different viral isolates are antigenically identical but are not related to the major structural proteins of other retroviruses. Antibodies to LAV p25 are predominantly found in the sera of patients with AIDS or with pre-AIDS but in some cases, antibodies to pl8 and pl3 are also detected. These results confirm that the various LAV isolates represent a new human retroviruses associated with AIDS.
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Barre-Sinoussi, F., Chermann, J.C., Montagnier, L. (1985). Analysis and Immunological Properties of Lymphadenopathy Associated Virus (LAV) Structural Proteins. In: Gallo, R.C., Stehelin, D., Varnier, O.E. (eds) International Symposium: Retroviruses and Human Pathology. Experimental Biology and Medicine, vol 11. Humana Press. https://doi.org/10.1007/978-1-4612-5008-1_30
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DOI: https://doi.org/10.1007/978-1-4612-5008-1_30
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