Antigen-Specific T Cell Helper Factors

  • James N. Woody
  • Jonathan R. Lamb
  • Edward D. Zanders
  • Marc Feldman
Part of the Experimental Biology and Medicine book series (EBAM, volume 9)


The mechanism by which antigen-specific T helper cells convey information to their B cell counterparts has received much attention in the immunologic literature. Recent studies with cloned T helper cells indicate that antigen-specific T helper factors (THF), capable of inducing specific antibody responses, are actively secreted in response to antigenic restimulation. Serologic analysis of such factors suggest the presence of constant and variable regions, as well as products of class II histocompatibility genes. Current models suggest that THF represents the secreted variant form of the T cell receptor.


Helper Cell Beta Chain Secrete Form Serologic Analysis Specific Antibody Response 
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Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • James N. Woody
    • 1
  • Jonathan R. Lamb
    • 2
  • Edward D. Zanders
    • 2
  • Marc Feldman
    • 2
  1. 1.Transplantation Research Program CenterNaval Medical Research InstituteBethesdaUSA
  2. 2.Imperial Cancer Research Fund, Tumor Immunology UnitUniversity CollegeLondonUK

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