Abstract
Phorbol esters are a family of compounds which act as tumour promoters in experimental animals and induce a variety of phenotypic changes as detected in cultured cells(1.2.). Studies of the cellular action of phorbol esters revealed that they act synergistica11y with many growth factors (platelet derived growth factor, epidermal growth factor) to induce DNA synthesis but fail to synergise with others (vasopressin, bombesin) (3.4.). These results suggest that the metabolic pathways for mitogenic effect utilised by phorbol esters and hormones are closely related.
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References
Cassel, L.D., Hoxie, J.A. and Cooper, R.A., Cancer Res. 43, 4582–4586 (1983)
Delia, D., Greaves, M.F., Newman, R.A., Sutherland, D.R., Minowada, J., Kung, P. and Goldstein, G., Int. J. Cancer 29, 123-J31 (1982)
Decker, P. and Rozengurt, E, Nature 287, 607–612 (1980)
Rozengurt, E. and Collins, M., Pathology 141, 309–331 (1983)
Ando, I., Hariri, G., Wallace, D., Beverley, P.C.L., Eur.J.Immuno1. (in press)
Ando, I., Crawford, D.H., Kissonerghis, M.A., Owen, M.J., Beverley, P.C.L., Eur.J.Immunol (in press)
Ando, I., Crawford, D.H., Beverley, P.C.L., in proceedings of the second international workshop on Leucocyte differentiation antigens (in press)
Beverley, P.C.L., and Callard, R.E., Eur. J. Immunol, 11, 329–334 (1981)
Tax, W.J.M., Willems, H.W., Reekers, P.P.M., Capel, P.J.A. and Koene, R.A.P., Nature 304, 445–447 (1983)
Uchiyama, T., Nelson, D.C., Fleisher, T.A. and Waldman, T.A., J. Immunol. 126, 1398–1403 (1981)
Catt, K.J., Harwood, J.P., Aguilera, G., Dufau, M.L,. Nature 280, 109–116 (1979
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Ando, I. et al. (1985). Phorbol Ester Induced Modulation of Lymphocyte Phenotype and Function. In: Feldmann, M., Lamb, J.R., Woody, J.N. (eds) Human T Cell Clones. Experimental Biology and Medicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4998-6_31
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DOI: https://doi.org/10.1007/978-1-4612-4998-6_31
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