Self Education after Mismatched HLA Haploidentical Bone Marrow Transplantation
Animal models of major histocompatibility complex (MHC) incompatible bone marrow transplantation have gained considerable insight into the understanding of self education mechanism. It has been shown that the Ia molecules expressed on intrathymic cells inprint the self recognition pattern of engrafted MHC incompatible T cells and thus tolerance to host cells (1,2,3). The origin of the Ia positive cells present into the thymus is only dependent from the dose of irradiation delivered to the host (4,5). In the thymus of 900 rads-irradiated mice, one finds host-derived Ia+ cells resulting in self tolerance to host Ia antigen by engrafted T cells whereas in the thymus of 1,200 rads-irradiated mice there are firstly host Ia bearing cells, then bone marrow derived, donor type Ia+ cells which dictate both host and donor Ia to be viewed as self (4,5).
KeywordsInfluenza Cyclosporin Thymidine Quinacrine Agammaglobulinemia
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