The Chemistry of Antigen-Antibody Union

  • Elizabeth D. Getzoff
  • John A. Tainer
  • Richard A. Lerner
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 8)

Abstract

A complete understanding of the cellular immune response requires a detailed knowledge of the structural basis for protein antigenicity at a molecular level that approaches atomic resolution. Both site-specific anti-peptide antibodies1.2 and monoclonal anti-protein antibodies against proteins of known three-dimensional structure3 allow examination of the molecular and chemical basis for antigen-antibody interaction. Our experiments suggest that antigenic recognition can be divided into at least three stages: l) precollision orientation by electrostatic forces, 2) local antibody-antigen recognition involving the interaction of specific residues, and 3) induced fit accomplished by local rearrangments of epitope and paratope structure. Here we report on experiments concerning precollision orientation and induced fit, as the influence of specific residues on antigenic recognition is well documented elsewhere3.

Keywords

Lactate Catalysis Rubber Influenza Lysine 

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Copyright information

© The Humana Press Inc. 1985

Authors and Affiliations

  • Elizabeth D. Getzoff
    • 1
  • John A. Tainer
    • 1
  • Richard A. Lerner
    • 1
  1. 1.Department of Molecular BiologyResearch Institute of Scripps ClinicLa JollaUSA

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