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Regulation of human B lymphocytes differentiation: Characterization of B cell stimulatory factors

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Immune Regulation

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 8))

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Abstract

B lymphocytes originate from pluripotent hematopoietic stem cells and differentiate into antibody producing cells through several distinct differentiation stages. Commitment of the antigen specificity in each B cell clone occurs at the stage of pre B cells by two step DNA rearrangements including V, D and J segments, i.e. from DJ joining to the functional VDJ formation (1). Following the rearrangement of heavy chain genes, light chain gene rearrangements occur (2) and 7S IgM molecules are expressed as antigen receptors on the surface of mature B cells. A given antigen selects a B cell clone with a matched receptor and activates this clone into antibody producing cells under the influence of helper T cells.

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Author information

Authors and Affiliations

  1. Institute for Molecular and Cellular Biology, Osaka University, 1-3, Yamada-Oka, Suita city, Osaka, Japan

    T. Hirano, H. Kikutani, K. Shimizu, H. Kishi, T. Taga, K. Ishibashi, S. Inui, S. Kashiwamura, N. Nakano, Y. Miki, T. Nakagawa & T. Kishimoto

Authors
  1. T. Hirano
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  2. H. Kikutani
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  3. K. Shimizu
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  4. H. Kishi
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  5. T. Taga
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  6. K. Ishibashi
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  7. S. Inui
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  8. S. Kashiwamura
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  9. N. Nakano
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  10. Y. Miki
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  11. T. Nakagawa
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  12. T. Kishimoto
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Editor information

Editors and Affiliations

  1. Middlesex Hospital Medical School, London, UK

    Marc Feldmann

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© 1985 The Humana Press Inc.

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Hirano, T. et al. (1985). Regulation of human B lymphocytes differentiation: Characterization of B cell stimulatory factors. In: Feldmann, M., Mitchison, N.A. (eds) Immune Regulation. Experimental Biology and Medicine, vol 8. Humana Press. https://doi.org/10.1007/978-1-4612-4996-2_12

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  • DOI: https://doi.org/10.1007/978-1-4612-4996-2_12

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-9390-3

  • Online ISBN: 978-1-4612-4996-2

  • eBook Packages: Springer Book Archive

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