Abstract
The process of haemopoiesis provides a heterogenous population of peripheral blood cells with diverse morphological characteristics and functions. The site of production of these cells is mainly the bone marrow in the adult animal. In the marrow resides a population of pluripotent stem cells which give rise to the mature blood cells (see l). These stem cells can either self-renew (that is, form exact copies of themselves) or differentiate depending on the needs of the organism, in this way the stem cell population can be maintained throughout a life-time (and in fact could be maintained throughout several lifetimes2). A stem cell can also give rise to a series of progenitor cells upon division that are the precursor cells of the different lineages or blood cell types found in the circulation (see 3). The progeny of a p1uripotential stem cell are committed to a defined differentiation pathway whereby there is a restriction as to which mature blood cell type they will be able to yield4.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Metcalf, D. and Moore, M.A.S. in Haemopoietic cells 550pp (Amsterdam North Holland, 1971).
Harrison, D.E. Proc.Nat 1.Acad.Sci., U.S.A. 70, 3184–3188 (1973).
Till, J.E. and McCulloch, E.A. Biochim. Biophys. Acta. 605, 431–459 (1980)
Metcalf, D. in Hemopoietic Colonies in vitro. Cloning of Normal and Leukemic Cells, 227pp. (Springer Verlag, 1977).
Miyake, T., Kung, C.K.H. and Goldwasser, E. J. Biol. Chem. 252, 5558–5564 (1977).
Stanley, E.R. et al. J. Cell Biochem. 21, 151–159 (1983).
Metcalf, D. in Tissue Growth Factors (ed. Baserga, R) 343–384 (Springer-Verlag, 1981).
Burgess, A.W. et al. Biochem. J. 185, 301–314 (1982).
Allen, T.D. and Dexter, T.M. Differentiation, 6,191–194 (1976).
Dexter, T.M. et al. J Supermol. Struct. 13, 513–524 (1980)
Bazil, G.W. et al. Biochem. J. 210,747–759 (1983).
Iscove, N.N. et al. J. cell physiol. (suppl)1,65–78 (1982).
Ihle, J. et al. Immunol. Rev.63,532–549 (1982).
Tokota T. et al. Proc. Natl. Acad. Sci., U.S.A. 81, 1070–1074 (1984).
Schräder, J.W. Crit. Rev. Immunol. 4, 197–277 (1983).
Dexter T.M. et al. J. Exp. Med. 152, 1036–1047 (1980).
Greenberger, J.S. J. Supramol. Struct. 13, 501–514 (1982).
Whetton, A.D. and Dexter, T.M. Nature (London) 303, 629–631 (1983).
Whetton, A.D., Bazill, G.W. and Dexter, T.M. EMBO J. 3, 409–413 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 The Humana Press Inc.
About this chapter
Cite this chapter
Whetton, A.D., Dexter, T.M. (1985). Haemopoietic Cell Growth Factor: Characterisation and Mode of Action. In: Feldmann, M., Mitchison, N.A. (eds) Immune Regulation. Experimental Biology and Medicine, vol 8. Humana Press. https://doi.org/10.1007/978-1-4612-4996-2_11
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4996-2_11
Publisher Name: Humana Press
Print ISBN: 978-1-4612-9390-3
Online ISBN: 978-1-4612-4996-2
eBook Packages: Springer Book Archive