Cleavage Site Mutant As a Potential Vaccine

  • Morio Homma

Abstract

Cleavage of the envelope glycoprotein of paramyxoviruses [1–3] and influenza viruses [4–7] is accomplished by a host protease. By this means, virus becomes activated, causes hemolysis, cell fusion, and infectivity. The presence of the protease allows the virus to replicate in multiple cycles. In contrast, in the absence of protease, replication is limited to a single cycle.

Keywords

Influenza Electrophoresis Polypeptide Trypsin Peri 

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© Springer Science+Business Media New York 1986

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  • Morio Homma

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