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Hepatitis B Virus and Cancer

  • Chapter
Concepts in Viral Pathogenesis II

Abstract

There is much evidence suggesting a close association between hepatitis B virus (HBV) infection and the development of primary hepatocellular carcinoma (PHC), although the mechanism by which HBV participates in the development of PHC remains to be elucidated. The importance of this relationship to public health can be appreciated by the fact that PHC is the most common cancer in the world (at least 250,000 new cases annually), that there are approximately 200 million HBV carriers worldwide, and that persistent infection with HBV may be required for the development of PHC [1–3]. The latter point is supported by much epidemiological data, including a study showing that the relative risk of HBV carriers developing PHC as compared to noncarriers is more than 200, which is one of the highest relative risks known for a human cancer [4]. In some populations, the lifetime risk of chronic carriers developing PHC is as high as 50% in males, and almost half of all deaths in carriers 40 years or older have been attributed to PHC [4,5]. A better understanding of this relationship at cellular and molecular levels, then, will have a significant impact upon public health.

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References

  1. Vyas GN, Blum HE, (1984) Hepatitis B virus infection. Western J Med 140: 754–762

    CAS  Google Scholar 

  2. Blumberg BS, London WT, (1982) Hepatitis B virus: Pathogenesis and prevention of primary cancer of the liver. Cancer 50: 2657 - 2665

    CAS  PubMed  Google Scholar 

  3. Szmuness W, (1978) Hepatocellular carcinoma and hepatitis B virus: Evidence for a causal association. Prog Med Virol 24: 40–69

    CAS  PubMed  Google Scholar 

  4. Beasley RP, Hwang L-Y, (1984) Epidemiology of hepatocellular carcinoma. In Vyas GN, Dienstag JL, Hoofnagle JH (eds) Viral Hepatitis and Liver Disease. Grune and Stratton, New York, pp 209–224

    Google Scholar 

  5. Robinson WS, Miller RH, Marion PL, (1983) Hepatitis B virus as an environmental carcinogen. In Milman HA, Sell S (eds) Application of Biological Markers to Carcinogen Testing. Plenum Publishing Corp, New York, pp 465–473

    Chapter  Google Scholar 

  6. Smuckler EA, Ferrell L, Clawson GA, (1984) Proliferative hepatocellular lesions, benign and malignant. In Vyas GN, Dienstag JL, Hoofnagle JH (eds) Viral Hepatitis and Liver Disease. Grune and Stratton, New York, pp 201–207

    Google Scholar 

  7. Berenblum I, (1985) Challenging problems in cocarcinogenesis. Cancer Res 45: 1917–1921

    CAS  PubMed  Google Scholar 

  8. Rizzetto M, (1983) The delta agent. Hepatology 3: 729–737

    Article  CAS  PubMed  Google Scholar 

  9. Ray MB, (1979) Hepatitis B Virus Antigens in Tissues. University Park Press, Baltimore, MD, pp 1–59

    Book  Google Scholar 

  10. Urban MK, O’Connell AP, London WT, (1985) Sequence of events in natural infection of Pekin duck embryos with duck hepatitis B virus. J Virol 55: 16–22

    CAS  PubMed Central  PubMed  Google Scholar 

  11. Snyder RL, Summers J, (1980) Woodchuck hepatitis virus and hepatocellular car¬cinoma. In Essex M, Todaro E, zur Hausen H (eds) Virus in Naturally Occurring Cancers. Cold Spring Harbor Conferences on Cell Proliferation. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 447–457

    Google Scholar 

  12. Feitelson MA, (1985) In Becker Y, Hadar J (eds) Molecular Components of Hepatitis B Virus. Martinus Nijhoff Publishing, Boston, pp 1–273

    Chapter  Google Scholar 

  13. Shafritz DA, Rogler CE, (1984) Molecular characterization of viral forms observed in persistent hepatitis infections, chronic liver disease and hepatocellular carcinoma in woodchucks and humans. In Vyas GN, Dienstag JL, Hoofnagle JH (eds) Viral Hepatitis and Liver Disease. Grune and Stratton, New York, pp 225–243

    Google Scholar 

  14. Fausto N, Shank PR, (1983) Oncogene expression in liver regeneration and he- patocarcinogenesis. Hepatology 3: 1016–1023

    Article  CAS  PubMed  Google Scholar 

  15. Shaul Y, Rutter WJ, Laub O, (1985) A human hepatitis B viral enhancer element. EMBO J 4: 427–430

    CAS  Google Scholar 

  16. Varmus HE, (1984) Do hepatitis B viruses make a genetic contribution to primary hepatocellular carcinoma? In Vyas GN, Dienstag JL, Hoofnagle JH (eds) Viral Hepatitis and Liver Disease. Grune and Stratton, New York, pp 411–414

    Google Scholar 

  17. Rogler CE, Sherman M, Su CY, Shafritz DA, Summers J, Shows TB, Henderson A, Kew M, (1985) Deletion in chromosome lip associated with a hepatitis B integration site in hepatocellular carcinoma. Science 230: 319–322

    Article  CAS  PubMed  Google Scholar 

  18. Kew MC, Dusheiko GM, Hadziyannis SJ, Patterson A, (1984) Does delta infection play a part in the pathogenesis of hepatitis B virus related hepatocellular carcinoma? Br Med J 288: 1727

    Article  CAS  Google Scholar 

  19. Dejean A, Sonigo P, Wain-Hobson S, Tiollais P, (1984) Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat. Proc Natl Acad Sei USA 81: 5350–5354

    Article  CAS  Google Scholar 

  20. Bishop JM, (1985) Viral oncogenes. Cell 42:23-38

    Article  CAS  PubMed  Google Scholar 

  21. Petit M-A, Pillot J, (1985) HBc and HBe antigenicity and DNA binding activity of major core protein p22 in hepatitis B virus core particles isolated from the cytoplasm of human liver cells. J Virol 53: 543–551

    CAS  PubMed Central  PubMed  Google Scholar 

  22. Feitelson MA, Marion PL, Robinson WS, (1982) The core particles of HBV and GSHV. II. Characterization of the protein kinase reaction associated with ground squirrel hepatitis virus and hepatitis B virus. J Virol 43: 741–748

    CAS  PubMed Central  PubMed  Google Scholar 

  23. Miller RH, Robinson WS, (1983) Integrated hepatitis B virus DNA sequences specifying the major viral core polypeptide are methylated in PLC/PRF/5 cells. Proc Natl Acad Sei USA 80: 2534–2538

    Article  CAS  Google Scholar 

  24. Yoakum GH, Korba BE, Lechner JF, Tokiwa T, Gazdar AF, Seeley T, Siegel M, Leeman L, Autrup H, Harris CC, (1983) High-frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells. Science 222: 385–389

    Article  CAS  PubMed  Google Scholar 

  25. Ou JH, Rutter WJ, (1985) Hybrid hepatitis B virus-host transcripts in a human hepatoma cell. Proc Natl Acad Sei USA 82: 83–87

    Article  CAS  Google Scholar 

  26. Wen Y-M, Mitamura K, Merchant B, Tang ZY, Purcell RH, (1983) Nuclear antigen detected in hepatoma cell lines containing integrated hepatitis B virus DNA. Infect Immun 39: 1361–1367

    CAS  PubMed Central  PubMed  Google Scholar 

  27. Koshy R, Freytag von Loringhoven ABL, Koch S, Marquardt O, Hofschneider PH, (1984) Structure and function of integrated HBV genes in the human hepatoma cell line PLC/PRF/5. In Vyas GN, Dienstag JL, Hoofnagle JH (eds) Viral Hepatitis and Liver Disease. Grune and Stratton, New York, pp 265–273

    Google Scholar 

  28. Robinson WS, Miller RH, Klote L, Marion PL, Lee S-C, (1984) Hepatitis B virus and hepatocellular carcinoma. In Vyas GN, Dienstag JL, Hoofnagle JH (eds) Viral Hepatitis and Liver Disease. Grune and Stratton, New York, pp 245–263

    Google Scholar 

  29. Klein G, Klein E, (1985) Evolution of tumors and the impact of molecular oncology. Nature 315: 190–195

    Article  CAS  PubMed  Google Scholar 

  30. Tur-Kasta R, Burk RD, Shaul Y, Shafritz DA, (1986) Hepatitis B virus DNA contains a glucocorticoid-responsive element. Proc Natl Acad Sei USA 83: 1627–1631

    Article  Google Scholar 

  31. Reynolds SH, Stowers SJ, Marondot R, Anderson MW, Aaronson SA, (1986) Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse. Proc Natl Acad Sei USA 83: 33–37

    Article  CAS  Google Scholar 

  32. Koufos A, Hansen MF, Copeland NG, Jenkins NA, Lampkin BC, Cavenee WK, (1985) Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature 316: 330–334

    Article  CAS  PubMed  Google Scholar 

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Authors
  1. Mark A. Feitelson
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Editors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, Bethesda, Maryland, 20892, USA

    Abner Louis Notkins M.D.

  2. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1986 Springer Science+Business Media New York

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Feitelson, M.A. (1986). Hepatitis B Virus and Cancer. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4958-0_32

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  • DOI: https://doi.org/10.1007/978-1-4612-4958-0_32

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9375-0

  • Online ISBN: 978-1-4612-4958-0

  • eBook Packages: Springer Book Archive

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