Pathogenesis of Parvovirus-induced Disease in Humans
In 1975, Cossart and colleagues  described parvovirus-like particles in human sera. The subsequent indentification of the genome as a single piece of single-stranded DNA of about 5.5 kilobases  encapsidated within two or three proteins (MW 48,000, 80,000, and possibly 68,000) (, and unpublished) has confirmed that this virus belongs to the family Parvoviridae. More recent works suggests that although the virus has not been propagated in tissue culture, it is likely to be capable of autonomous replication; the terminal palindromic sequences of the 3′ end are not complementary to those at the 5′ end, contrary to findings in dependoviruses .
KeywordsHereditary Spherocytosis Erythroid Progenitor Cell Aplastic Crisis Erythema Infectiosum Erythroid Colony Formation
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