Pathogenesis of Parvovirus-induced Disease in Humans

  • M. J. Anderson
  • J. R. Pattison
  • Neal S. Young


In 1975, Cossart and colleagues [1] described parvovirus-like particles in human sera. The subsequent indentification of the genome as a single piece of single-stranded DNA of about 5.5 kilobases [2] encapsidated within two or three proteins (MW 48,000, 80,000, and possibly 68,000) ([3], and unpublished) has confirmed that this virus belongs to the family Parvoviridae. More recent works suggests that although the virus has not been propagated in tissue culture, it is likely to be capable of autonomous replication; the terminal palindromic sequences of the 3′ end are not complementary to those at the 5′ end, contrary to findings in dependoviruses [4].


Hereditary Spherocytosis Erythroid Progenitor Cell Aplastic Crisis Erythema Infectiosum Erythroid Colony Formation 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • M. J. Anderson
  • J. R. Pattison
  • Neal S. Young

There are no affiliations available

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