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Concepts in Viral Pathogenesis II pp 248–254Cite as

Theiler’s Murine Encephalomyelitis Virus (TMEV) Infection in Mice as a Model for Multiple Sclerosis

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Abstract

Theiler’s murine encephalomyelitis viruses (TMEV) are enteric pathogens of mice and members of the Picornaviridae family. The nucleotide sequence of TMEV and the predicted amino acid sequences of the TMEV-encoded proteins have been compared with other picornaviruses, and a close relationship exists with encephalomyocarditis virus (EMCV), indicating that the TMEV belong to the cardiovirus subgroup of picornaviruses. However, the type of neurologic involvement the TMEV produce is quite distinct from that of other cardioviruses. Following intracerebral (IC) inoculation, certain TMEV strains produce a unique biphasic central nervous system (CNS) disease in their natural murine host [1,2], characterized by poliomyelitis during the first month post infection, and a chronic, inflammatory demyelinating disorder weeks to months later in surviving animals. Mice infected with tissue culture-adapted TMEV do not develop clinical polio but do develop demyelinating disease after a prolonged (30–60 days) incubation period [3]. The demyelination is related to persistent infection wherein for many months low levels of infectious virus can be recovered from the target organ, the CNS [1,4].

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References

  1. Lipton HL (1975) Theiler’s virus infection in mice: An unusual biphasic disease process leading to demyelination. Infect Immun 11: 1147–1155

    CAS  PubMed Central  PubMed  Google Scholar 

  2. Lehrich JR, Arnason BGW, Hochberg F (1976) Demyelinative myelopathy in mice induced by the DA virus. J Neurol Sci 29: 149–160

    Article  CAS  PubMed  Google Scholar 

  3. Lipton HL, Dal Canto (1979) The TO strains of Theiler’s viruses cause “slow viruslike” infections in mice. Ann Neurol 6: 25–28

    Article  CAS  PubMed  Google Scholar 

  4. Theiler M (1937) Spontaneous encephalomyelitis of mice, a new virus disease. J Exp Med 65: 705–719

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  5. Dal Canto MC, Lipton HL (1976) Primary demyelination in Theiler’s virus infection. J Lab Invest 33: 626–637

    Google Scholar 

  6. Dal Canto MC, Lipton HL (1980) Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler’s virus. Am J Pathol 98: 101–110

    Google Scholar 

  7. Dal Canto MC, Barbano RL (1985) Immunocytochemical localization of MAG, MBP, P0 and P0 protein in acute and relapsing demyelinating lesions of Theiler’s virus infection. J Neuroimmunol 10: 129–140

    Article  Google Scholar 

  8. Lipton HL, Melvold RM (1984) Genetic analysis of susceptibility to Theiler’s virus-induced demyelinating disease in mice. J Immunol 132: 1821–1825

    CAS  PubMed  Google Scholar 

  9. Clatch RJ, Melvold RW, Miller SD, Lipton HL (1985) Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: Correlation with TMEV-specific delayed-type hypersensitivity. J Immunol 135: 1408–1414

    CAS  PubMed  Google Scholar 

  10. Rodriguez M, David CS (1985) Demyelination induced by Theiler’s virus: Influence of the H-2 haplotype. J Immunol 135: 2145–2148

    CAS  PubMed  Google Scholar 

  11. Melvold RM, Knobler RL, Lipton HL (1986) (submitted)

    Google Scholar 

  12. Brahic M, Haase AT, Cash E (1984) Simultaneous in situ detection of viral RNA and antigens. Proc Natl Acad Sci USA 81: 5445–5448

    Article  CAS  PubMed  Google Scholar 

  13. Cash E, Chomorro M, Brahic M (1985) Theiler’s virus RNA and protein synthesis in the central nervous system of demyelinating mice. Virology 144: 290–294

    Article  CAS  PubMed  Google Scholar 

  14. Dal Canto MC, Lipton HL (1982) Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler’s virus infection. Am J Pathol 106: 20–29

    Google Scholar 

  15. Rodriguez M, Liebowitz JL, Lampert PW (1983) Persistent infection of oligodendrocytes in Theiler’s virus-induced encephalomyelitis. Ann Neurol 13: 426–433

    Article  CAS  PubMed  Google Scholar 

  16. Brahic M, Stroop WG, Baringer JR(1981) Theiler’s virus persists in glial cells during demyelinating disease. Cell 26: 123–128

    Google Scholar 

  17. Chamarro M, Aubert C, Brahie M (1986) The demyelinating lesions due to Theiler’s virus are associated with ongoing CNS infection. J Virol 57: 992–997

    Google Scholar 

  18. Clatch RJ, Lipton HL, Miller SD (1986) Characterization of Theiler’s murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: Correlation with clinical signs. J Immunol 136: 920–927

    CAS  PubMed  Google Scholar 

  19. MacKaness GB (1964) The immunologic basis of acquired cellular resistance. J Exp Med 120: 105–120

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Wisniewski HM, Bloom BR (1975) Primary demyelination as a nonspecific consequence of a cell-mediated immune reaction. J Exp Med 141: 346–359

    Article  CAS  PubMed  Google Scholar 

  21. Holoshitz J, Naparstek Y, Ben-Nun A, Marquardt P, Cohen IR (1984) T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity, and bystander encephalitis or arthritis. Eur J Immunol 14: 729–734

    Article  CAS  PubMed  Google Scholar 

  22. Powell HC, Braheny SL, Hughes RAC, Lampert PW (1984) Antigen-specific demyelination and significance of the bystander effect in peripheral nerves. Am J Pathol 114: 443–453

    CAS  PubMed  Google Scholar 

  23. Reddehase MJ, Koszinowski UH (1984) Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection. Nature 131: 369–371

    Article  Google Scholar 

  24. Gooding LR, O’Connell KA (1983) Recognition by cytotoxic T lymphocytes of cells expressing fragments of the SV40 tumor antigen. J Immunol 131: 2580–2586

    CAS  PubMed  Google Scholar 

  25. Tevethia SS, Tevethia MJ, Lewis AJ, Reddy UB, Weissman SM (1983) Biology of simian virus 40 (SV40) transplantation antigen (TrAg). IX. Analysis of TrAg in mouse cells synthesizing truncated SV40 large T antigen. Virology 128: 319–330

    Article  CAS  PubMed  Google Scholar 

  26. Townsend ARM, McMichael AJ, Carter NP, Huddleston JA, Brownlee CG (1984) Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in tranfected mouse L cells. Cell 39: 13–25

    Article  CAS  PubMed  Google Scholar 

  27. Huber SA, Job LP, Woodruff JF (1984) In vitro culture of coxsackievirus group B, type 3 immune spleen cells on infected endothelial cells and biologic activity of the cultured cells in vivo. Infect Immun 43: 567–573

    CAS  PubMed Central  PubMed  Google Scholar 

  28. Barbano RL, Dal Canto MC (1984) Serum and cells from Theiler’s virus-infected mice fail to injure myelinating cultures or to produce in vitro transfer to disease. J Neurol Sci 66: 283–293

    Article  CAS  PubMed  Google Scholar 

  29. Jahnke U, Fischer EH, Alvord EC Jr (1985) Sequence homology between certain viral proteins and proteins related to encephalomyelitis and neuritis. Science 229: 282–284

    Article  CAS  PubMed  Google Scholar 

  30. Fujinami RS, Oldstone MBA (1985) Amino acid homology between the encephalogenic site of myelin basic protein and virus: A mechanism for autoimmunity. Science 230: 1043–1045

    Article  CAS  PubMed  Google Scholar 

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Authors
  1. Howard Lipton
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  2. Stephen Miller
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  3. Roger Melvold
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  4. Robert S. Fujinami
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Editor information

Editors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, Bethesda, Maryland, 20892, USA

    Abner Louis Notkins M.D.

  2. Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California, 92037, USA

    Michael B. A. Oldstone M.D.

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© 1986 Springer Science+Business Media New York

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Lipton, H., Miller, S., Melvold, R., Fujinami, R.S. (1986). Theiler’s Murine Encephalomyelitis Virus (TMEV) Infection in Mice as a Model for Multiple Sclerosis. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4958-0_29

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  • DOI: https://doi.org/10.1007/978-1-4612-4958-0_29

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9375-0

  • Online ISBN: 978-1-4612-4958-0

  • eBook Packages: Springer Book Archive

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