Oncogenes, Growth Factors, and Receptors

  • Steven R. Tronick
  • Stuart A. Aaronson


Acutely transforming retroviruses are among the most carcinogenic agents known. Because of this property, they have been studied extensively [1]. The model systems provided by these viruses have proven to be valuable sources of information not only on the mechanisms by which normal cells become malignant, but also on how they grow and differentiate. The acutely transforming retroviruses contain genes, termed oncogenes, that are responsible for causing tumors in animals and inducing the malignant phenotype in cultured cells. Viral oncogenes have counterparts in normal cells, termed proto-oncogenes [2], and detailed analyses of the corresponding viral and cellular sequences have revealed that viral oncogenes arose as a result of the acquisition (by as yet ill-defined recombinational events) of portions of proto-oncogenes by replication-competent retroviruses [2]. These findings have implied the existence of a subset of normal cellular genes with oncogenic potential.


Epidermal Growth Factor Receptor Cellular Gene Viral Oncogene Oncogene Product Human Insulin Receptor 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Steven R. Tronick
  • Stuart A. Aaronson

There are no affiliations available

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