Abstract
Graft-versus-host disease (GvHD) is a major complication after allogeneic bone marrow (BM) transplantation. The disease is considered to be the result of an immunological reaction of donor T-cells against host antigens that are disparate to the donor (1). Removal of donor T-cells has been shown to prevent acute GvHD in various species, i.e., mice (2), dogs (3) and rhesus monkeys (4,5). In vitro treatment of bone marrow grafts with monoclonal antibodies (MCAs) against human T-cells has been used for the prevention of GvHD in humans (6,7, 8). These attempts have been successful when HLA-identical sibling donors were used, but the majority of the potentially useful MCAs have not been tested in the more stringent mismatched donor-recipient combinations. GvHD prevention by T-cell depletion is counterbalanced by an increased frequency of take failures, as was first observed in dogs (9,10) and rhesus monkeys (4). This was also encountered in humans, especially when partially mismatched donor-recipient combinations were used (11,12).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Van Bekkum DW (1964). The selective elimination of immunologically competent cells from bone marrow and lymphatic cell mixtures. Transplantation 2, 393
Dicke KA, van Hooft JIM, van Bekkum DW (1968). The selective elimination of immunologically competent cells from bone marrow and lymphatic cell mixtures. Transplantation 6, 562.
Kolb HJ, Rieder I, Rodt H et al. (1979). Antilymphocytic antibodies and marrow transplantation. VI. Graft-versus-host tolerance in DLA-incompatible dogs after in vitro treatment of bone marrow with absorbed antithymocyte globulin. Transplantation 27, 1979.
Wagemaker G, Heidt PJ, Merchav S, van Bekkum DW (1982). Abrogation of histocompatibility barriers to bone marrow transplantation in rhesus monkeys. In: Baum SJ et al (eds) Haematology Today 1982, Basel: S.Karger, p 111.
Dicke KA, van Bekkum DW (1970). Avoidance of acute secondary disease by purification of hematopoietic stem cells with density gradient centrifugation. Exp Hematol (Oak Ridge Series) 20, 126.
Waldmann H, Hale C, Cividalli G et al (1984). Elimination of graftversus-host disease by in vitro depletion of alloreactive lymphocytes with a monoclonal rat antihuman lymphocyte antibody (CAMPATH-1). Lancet 483.
Prentice HG, Janossy G, Price-Jones L et al (1984). Depletion of Tlymphocytes in donor marrow pre vents significant graft-versus-host disease in matched allogeneic leukaemic marrow transplant recipients. Lancet 472.
Martin PJ, Hansen JA, Storb R, Thomas ED (1985). A clinical trial of in vitro depletion of T-cells in donor marrow for prevention of acute graft-versus-host disease. Transplant Proc 17, 486.
Vriesendorp HM, Wagemaker G, van Bekkum DW (1981). Engraftment of allogeneic bone marrow. Transplant Proc 13, 643.
Vriesendorp HM, Klapwijk WM, Heidt P et al (1982). Factors controlling the engraftment of transplanted bone marrow cells. Tissue Antigens 20, 63.
Sondel PM, Bozdech MJ, Trigg ME et al (1985). Additional immunosuppression allows engraftment following HLA-mismatched T-cell depleted bone marrow transplantation for leukemia. Transplant Proc 17, 460.
O’Reilly RJ, Collins NH, Kernan N et al (1985). Transplantation of marrow depleted T-cells by soybean lectin agglutination and E-rosette depletion: major histocompatibility complex related graft resistance in leukemic transplant recipients. Transplant Proc 17, 455.
Van Bekkum DW (1978). The rhesus monkey as a preclinical model for bone marrow transplantation. Transplant Proc 5, 105.
Schaefer UW, Dicke KA, Van Bekkum DW (1972). Recovery of haemopoiesis in lethally irradiated monkeys by frozen allogeneic bone marrow grafts. Rev Europ Etudes Clin et Biol 17, 483.
Broerse JJ, van Bekkum DW, Hollander CF, Davids JAG (1978). Mortality of monkeys after exposure to fission neutrons and the effect of autologous bone marrow transplantation. Int J Radiat Biol 34, 253.
Zurcher C, van Bekkum DW (1984). Pathology of radiation chimaeras. In: Van Bekkum van Lowenberg (eds )Bone marrow transplantation. Marcel Dekker, New York.
Hale G, Bright S, Chumbley G et al (1983). Removal of T-cells from bone marrow for transplantation: A monoclonal antilymphocyte antibody that fixes human complement. Blood 62, 873.
Tax WJM, Tidman N, Janossy G et al. (1984). Monoclonal antibody (WT-1) directed against a T cell surface glycoprotein: characteristics andimmunosuppressive activity. Clin exp Immunol 55, 427.
Fitchen JH, LeFevre C, Ferrone S, Cline MJ (1982). Expression of Ialike and HLA-A,B antigens on human multipotential hemapoietic progenitor cells. Blood 59, 188.
Fitchen JH, Ferrone S (1981). Expression of I-subregion antigens on murine hematopoietic stem cells.J Supramol Struct Cell Biochem Suppl 5, 107.
Visser JW, Bauman JGJ, Mulder AH, Eliason JF, de Leeuw AM (1984). Isolation of murine pluripotent hemopoietic stem cells. J Exp Med 59, 1576.
Levitt L, Kipps TJ, Engleman EG, Greenberg PL (1985). Human bone marrow and peripheral T lymphocyte depletion: efficacy and effects of both T cells and monocytes on growth of hematopoietic progenitors. Blood 65, 663.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Springer-Verlag New York Inc.
About this paper
Cite this paper
Gerritsen, W.R., Jonker, M., Wagemaker, G., van Bekkum, D.W. (1986). The Influence of T-Cell Depletion by Monoclonal Antibodies on Repopulating Hemopoietic Stem Cells and Their Efficacy in Preventing GvHD in Rhesus Monkeys. In: Baum, S.J., Pluznik, D.H., Rozenszajn, L.A. (eds) Experimental Hematology Today—1985. Experimental Hematology Today, vol 1985. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4920-7_20
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4920-7_20
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-96273-3
Online ISBN: 978-1-4612-4920-7
eBook Packages: Springer Book Archive