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Immunoglobulin and T-Cell Receptor Gene Rearrangements in Human Acute Leukemias

  • Conference paper
Experimental Hematology Today—1985

Part of the book series: Experimental Hematology Today ((HEMATOLOGY,volume 1985))

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Abstract

Development of immunological methods has made it possible to examine the cellular origin of leukemia cells in relation to their normal counterparts and acute lymphoblastic leukemia (ALL) is generally classified into the following major subgroups: T-ALL, B-ALL and common ALL (cALL) (1). Not infrequently, however, it is impossible to classify acute leukemias as B or T cell or nonlymphoid in origin despite examining lineage associated surface markers, as some malignancies represent stages of differentiation prior to the expression of lineage restricted surface markers. These limitations can now be overcome by utilizing the DNA rearrangement of immunoglobulin (Ig) and T cell receptor genes to reveal the clonality, cellular lineage, and stage of differentiation of such acute undifferentiated leukemias (AUL) (2).

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Authors and Affiliations

  1. DRK-Blutspendezentrale Ulm und Abteilung für Transfusionsmedizin der Universität Ulm, 7900, Ulm/Donau, Oberer Eselsberg 10, Federal Republic of Germany

    Anand Raghavachar, C. R. Bartram & Bernhard Kubanek

Authors
  1. Anand Raghavachar
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  2. C. R. Bartram
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  3. Bernhard Kubanek
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Editor information

Editors and Affiliations

  1. Physiology Department, Uniformed Services University of the Health Sciences, 20814, Bethesda, MD, USA

    S. J. Baum

  2. Laboratory of Microbiology and Immunology, National Institute of Dental Research, NIH, 29782, Bethesda, MD, USA

    Dov H. Pluznik

  3. Department of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel

    L. A. Rozenszajn

  4. Department of Medical Laboratories, Meir Hospital, Kfar-Sava, Israel

    L. A. Rozenszajn

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© 1986 Springer-Verlag New York Inc.

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Raghavachar, A., Bartram, C.R., Kubanek, B. (1986). Immunoglobulin and T-Cell Receptor Gene Rearrangements in Human Acute Leukemias. In: Baum, S.J., Pluznik, D.H., Rozenszajn, L.A. (eds) Experimental Hematology Today—1985. Experimental Hematology Today, vol 1985. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4920-7_14

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  • DOI: https://doi.org/10.1007/978-1-4612-4920-7_14

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96273-3

  • Online ISBN: 978-1-4612-4920-7

  • eBook Packages: Springer Book Archive

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