Abstract
One of the important functions of the leukocytes in the circulation is to participate in the body’s defense mechanisms against intrusion of foreign organisms or materials. A way to demonstrate this is by means of a local laser heat injury in the rabbit ear chamber (Grant, 1974). After the diffusion of inflammatory substances from the burn towards adjacent blood vessels, leuko-cytes adhere to the endothelium (Mayrovitz et al, 1980) and emigrate into tissue towards the site of the injury. In the bloodstream leukocytes are normally carried along passively by hydrodynamic forces, whereas their locomotion through the tissue is active. The cells create projections of the cytoplasmic membrane and cytoplasm beyond the perimeter of the undeformed shapes, and then achieve a displacement by attachment to and detachment from the substrate accompanied by relaxation. Figure 3.1 shows a proto- podium of a neutrophilic leukocyte projected underneath the endothelial cells.
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Schmid-Schönbein, G.W., Skalak, R., Chien, S. (1986). Leukocyte Protopodia. In: Schmid-Schönbein, G.W., Woo, S.LY., Zweifach, B.W. (eds) Frontiers in Biomechanics. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4866-8_3
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DOI: https://doi.org/10.1007/978-1-4612-4866-8_3
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