Advertisement

Vascular Dynamics and the Endothelium

  • R. M. Nerem
  • M. J. Levesque
  • M. Sato

Abstract

As the heart rhythmically beats and ejects its periodic output, there are a wide range of phenomena that take place as the pressure pulse propagates through the vascular system. Initially, the interest in vascular dynamics was simply on this phenomenon of wave propagation, and workers such as Young, Frank, Moens, and Korteweg are associated with this earliest phase of research on vascular dynamics. As part of any attempt to explain pulse wave propagation, however, it became necessary to study the elastic and viscoelastic nature of the arterial wall as well as the variation of such properties throughout the various segments of the arterial tree. With such studies, and during the 1950s and 1960s, our understanding of the development of pressure and flow in the systemic circulation (Vascular dynamics at a system level) made considerable progress. The names associated with this period include Womersley, McDonald, Taylor, Fung, and Bergel. These investigations have been reviewed by Fung (1981, 1984) and McDonald (1974), including contributions from more recent studies.

Keywords

Shear Stress Wall Shear Stress Shape Index Bovine Aortic Endothelial Cell Shear Stress Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bergel, D.H., ed. 1972. Cardiovascular fluid dynamics. Vols. 1 and 2. Academic Press, New York.Google Scholar
  2. Caplan, B.A., and Schwartz, C.J. 1973. Atherosclerosis 17: 401–417.CrossRefGoogle Scholar
  3. Caro, C.G., and Nerem, R.M. 1973. Circ. Res 32: 197–205.Google Scholar
  4. Caro, C.G., Pedley, T.J., Schroter, R.C., and Seed, W.A. 1978. The mechanics of the circulation. Oxford University Press, Oxford, England, U.K.Google Scholar
  5. Dewey, C.F., Jr. 1984. ASMEJ. Biomech. Eng 106: 31–35.CrossRefGoogle Scholar
  6. Dewey, C.F., Jr., Bussolari, S.R., Gimbrone, M.A., Jr., and Davies, P.F. 1981. ASMEJ. Biomech. Eng 103: 177–185.CrossRefGoogle Scholar
  7. Evans, E.A., and Skalak, R. 1979. Mechanics and thermodynamics of biomembrances. CRC critical reviews in bioengineering. Vol. 3, issues 3 and 4. CRC Press, Inc., Boca Raton, Florida.Google Scholar
  8. Frangos, J.A., Mclntire, L.V., Eskin, S.G. and Ives, C.L. (1985) Effects of flow on prostacyclin production by cultured human endothelial cells. Science 227: 1477–1479.CrossRefADSGoogle Scholar
  9. Fry, D.L. 1968. Circ. Res 22: 165–197.Google Scholar
  10. _______.1969 Circ. Res 24: 93–108.Google Scholar
  11. Fung, Y.C. 1981. Biomechanics. Springer-Verlag, New York.Google Scholar
  12. _______.Biodynamics: circulation Springer-Verlag, New York.Google Scholar
  13. Gimbrone, M.A., Jr. 1976. Pages 1–28 in Progress in hemostasis and thrombosis. Vol. 3, T.H. Spaet, ed. Grune and Stratton, New York.Google Scholar
  14. McDonald, D.A. 1974. Blood flow in arteries. 2d d. Edward Arnold, London.Google Scholar
  15. Nerem, R.M. 1981. Pages 719–835 in Structure and function of the circulation,C.J. Schwartz and N. Werthesson, eds. Plenum Press, New York.Google Scholar
  16. Nerem, R.M., and Levesque, M.J. 1983. Pages 26–37 in Fluid dynamics as a localizing factor in atherosclerosis. Symposium proceedings. G. Schettler, et al, eds. Springer-Verlag, Heidelberg.Google Scholar
  17. Nerem, R.M., Levesque, M.J., and Cornhill, J.F. 1981. ASME J. Biomech. Eng 103: 172–176.CrossRefGoogle Scholar
  18. Repin, V.S., Dolgov, V.V., Zaikina, O.E., Novikov, J.D., Antonov, A.S., Nikolaeva, M.A., and Smironov, V.N. 1984. Atherosclerosis 50: 35–52.CrossRefGoogle Scholar
  19. Schettler, G., Nerem, R.M., Schmid-Schönbein, H., Morl, H., and Diehm, C., eds. 1983. Fluid dynamics as a localizing factor in atherosclerosis, Springer-Verlag, Heidelberg.Google Scholar
  20. Simionescu, M., Simionescu, N., and Palade, G.E. 1974. J. Cell Biol 60: 128–152.CrossRefGoogle Scholar
  21. Vaishnav, R.N., Patel, D.J., Atabek, H.B., Deshpande, M.D., Plowman, F., and Vossoughi, J. 1983. ASME J. Biomech. Eng 105: 77–83.CrossRefGoogle Scholar
  22. Weinbaum, S. 1983. Pages 92–114 in Ann. of New York Academy of Sciences: Surface Phenomena in Hemorheology: Their Theoretical, Experimental and Clinical Aspects. Vol. 416. A.L. Copley, GVF Simon, eds.Google Scholar
  23. White, C.E., Fujiwara, K., Shefton, E.J., Dewey, C.F., Jr., and Gimbrone, M.A., Jr. (1982) Federation Proc 41:321 (abst.).Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • R. M. Nerem
  • M. J. Levesque
  • M. Sato

There are no affiliations available

Personalised recommendations