Abstract
At the foundation of all pharmaceutical research is the assurance that any biological effects observed for a particular pharmaceutical preparation can be attributed to the active compound and not to impurities or components of the drug vehicle. Only when the exact chemical composition of a pharmaceutical preparation or, more specifically, its chemical purity (defined as the proportion, by mass, of a preparation in a specified chemical form) [1] is known can valid correlations between biological activity and chemical structure be made. Assurance of chemical purity and demonstration of sterility and apyrogenicity of a pharmaceutical preparation are particularly important in clinical applications in order for researchers to predict the nature of the biological response and to eliminate the possibility of unwanted pharmacologic or toxic effects.
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Mangner, T.J. (1986). Potential Artifacts in the Chromatography of Radiopharmaceuticals. In: Wieland, D.M., Tobes, M.C., Manger, T.J. (eds) Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4854-5_13
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DOI: https://doi.org/10.1007/978-1-4612-4854-5_13
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