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Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry pp 213–231Cite as

Concepts and Techniques Used in Metabolic Tracer Studies

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Abstract

Studies of ammonia, amino acid, fatty acid, and glucose metabolism have relied primarily on the use of 15N, 14C, 13C, and 3H-labeled compounds. However, tissue sampling and analysis of enriched metabolites, i.e., 15N and 13C by mass spectrometry [1] and NMR [2–4], and 14C and 3H by liquid scintillation counting, limit the application of these techniques for the noninvasive determination of in vivo tissue tracer kinetics.

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Authors
  1. Jorge R. Barrio
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  2. Randy E. Keen
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  3. Diane C. Chugani
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  4. Gerald Bida
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  5. Nagichettiar Satyamurthy
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  6. Michael E. Phelps
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Editors and Affiliations

  1. Division of Nuclear Medicine Department of Internal Medicine, The University of Michigan, 48109, Ann Arbor, MI, USA

    Donald M. Wieland , Michael C. Tobes  & Thomas J. Manger ,  & 

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Barrio, J.R., Keen, R.E., Chugani, D.C., Bida, G., Satyamurthy, N., Phelps, M.E. (1986). Concepts and Techniques Used in Metabolic Tracer Studies. In: Wieland, D.M., Tobes, M.C., Manger, T.J. (eds) Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4854-5_10

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