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Detection and Functional Studies of IL-2 Receptors on Activated Human B Cells

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Leukocyte Typing II

Abstract

Initial description of the IL-2 receptor identifiable by monoclonal antibody anti-Tac suggested that such receptors were specific for activated T cells (1). However, using monoclonal antibody AT1 developed in our laboratory, and which exhibits similar specificity to anti-Tac, we have been able to demonstrate the presence of this antigen on activated B cells. Furthermore, after appropriate activation, B cells have been found to respond to IL-2 by proliferation.

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References

  1. Uchiyama, T., S. Broder, and T.A. Waldmann. 1981. A monoclonal antibody (anti-Tac) reactive with activated and functional mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J. Immunol. 126:1393.

    PubMed  CAS  Google Scholar 

  2. Chiorrazi, N., S.M. Fu, and H.G. Kunkel. 1980. Stimulation of human B lymphocytes by antibodies to IgM and IgG: Functional evidence for the expression of IgG on B-lymphocyte surface membrane. Clin. Immunol. Immunopathol. 15:301.

    Article  Google Scholar 

  3. Yen, S.H., F. Gaskin, and S.M. Fu. 1983. Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class. Am. J. Pathol. 113:373.

    PubMed  CAS  Google Scholar 

  4. Mayer, L., S.M. Fu, and H.G. Kunkel. 1982. Human T cell hybridomas secreting factors for IgA: Specific help, polyclonal B cell activation and B cell proliferation. J. Exp. Med. 156:1860.

    Article  PubMed  CAS  Google Scholar 

  5. McCune, J.M., S.M. Fu, and H.G. Kunkel. 1981. J chain biosynthesis in pre- B cells and other possible precursor B cells. J. Exp. Med. 154:138.

    Article  PubMed  CAS  Google Scholar 

  6. Wang, C.Y., A. Al-Katib, C.L. Lane, B. Koziner, and S.M. Fu. 1983. Induction of HLA-DC/DS (Leu 10) antigen expression by human precursor B cell lines. J. Exp. Med. 158:1757.

    Article  PubMed  CAS  Google Scholar 

  7. Leonard, W.J., J.M. Depper, T. Uchiyama, K.A. Smith, T.A. Waldmann, and W.C. Greene. 1982. A monoclonal antibody that appears to recognize the receptor for human T cell growth factor; partial characterization of the receptor. Nature 300:267.

    Article  PubMed  CAS  Google Scholar 

  8. Muraguchi, A., J.H. Kehrl, D.L. Longo, D.J. Volkman, and A.S. Fauci. 1984. Tac expression on activated B cells and on a human T cell leukemia virus-infected B cell line. Fed. Proc. 43:1676.

    Google Scholar 

  9. Tsudo, M., T. Uchiyama, and H. Uchino. 1984. Expression of Tac antigen on activated normal human B cells. J. Exp. Med. 160:612.

    Article  PubMed  CAS  Google Scholar 

  10. Zubler, R.H., C. Mingarie, L. Moretta, and H.R. MacDonald. 1984. Effect of interleukin-2 on murine and human B cells. Fed. Proc. 43:1591.

    Google Scholar 

  11. Mond, J.J., C. Thompson, F.D. Finkelman, M. Schaefer, and R.J. Robb, 1984. Immuno-affinity purified interleukin-2 (IL-2) induces proliferation of large but not small B cells. Fed. Proc. 43:1591.

    Google Scholar 

  12. Howard, M., and W. Paul, 1983. Regulation of B cell growth and differentiation by soluble factors. Annu. Rev. Immunol. 1:307.

    Article  PubMed  CAS  Google Scholar 

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© 1986 Springer-Verlag New York Inc.

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Jung, L.K.L., Hara, T., Fu, S.M. (1986). Detection and Functional Studies of IL-2 Receptors on Activated Human B Cells. In: Reinherz, E.L., Haynes, B.F., Nadler, L.M., Bernstien, I.D. (eds) Leukocyte Typing II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4848-4_42

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  • DOI: https://doi.org/10.1007/978-1-4612-4848-4_42

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9328-6

  • Online ISBN: 978-1-4612-4848-4

  • eBook Packages: Springer Book Archive

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