Abstract
Initial description of the IL-2 receptor identifiable by monoclonal antibody anti-Tac suggested that such receptors were specific for activated T cells (1). However, using monoclonal antibody AT1 developed in our laboratory, and which exhibits similar specificity to anti-Tac, we have been able to demonstrate the presence of this antigen on activated B cells. Furthermore, after appropriate activation, B cells have been found to respond to IL-2 by proliferation.
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References
Uchiyama, T., S. Broder, and T.A. Waldmann. 1981. A monoclonal antibody (anti-Tac) reactive with activated and functional mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J. Immunol. 126:1393.
Chiorrazi, N., S.M. Fu, and H.G. Kunkel. 1980. Stimulation of human B lymphocytes by antibodies to IgM and IgG: Functional evidence for the expression of IgG on B-lymphocyte surface membrane. Clin. Immunol. Immunopathol. 15:301.
Yen, S.H., F. Gaskin, and S.M. Fu. 1983. Neurofibrillary tangles in senile dementia of the Alzheimer type share an antigenic determinant with intermediate filaments of the vimentin class. Am. J. Pathol. 113:373.
Mayer, L., S.M. Fu, and H.G. Kunkel. 1982. Human T cell hybridomas secreting factors for IgA: Specific help, polyclonal B cell activation and B cell proliferation. J. Exp. Med. 156:1860.
McCune, J.M., S.M. Fu, and H.G. Kunkel. 1981. J chain biosynthesis in pre- B cells and other possible precursor B cells. J. Exp. Med. 154:138.
Wang, C.Y., A. Al-Katib, C.L. Lane, B. Koziner, and S.M. Fu. 1983. Induction of HLA-DC/DS (Leu 10) antigen expression by human precursor B cell lines. J. Exp. Med. 158:1757.
Leonard, W.J., J.M. Depper, T. Uchiyama, K.A. Smith, T.A. Waldmann, and W.C. Greene. 1982. A monoclonal antibody that appears to recognize the receptor for human T cell growth factor; partial characterization of the receptor. Nature 300:267.
Muraguchi, A., J.H. Kehrl, D.L. Longo, D.J. Volkman, and A.S. Fauci. 1984. Tac expression on activated B cells and on a human T cell leukemia virus-infected B cell line. Fed. Proc. 43:1676.
Tsudo, M., T. Uchiyama, and H. Uchino. 1984. Expression of Tac antigen on activated normal human B cells. J. Exp. Med. 160:612.
Zubler, R.H., C. Mingarie, L. Moretta, and H.R. MacDonald. 1984. Effect of interleukin-2 on murine and human B cells. Fed. Proc. 43:1591.
Mond, J.J., C. Thompson, F.D. Finkelman, M. Schaefer, and R.J. Robb, 1984. Immuno-affinity purified interleukin-2 (IL-2) induces proliferation of large but not small B cells. Fed. Proc. 43:1591.
Howard, M., and W. Paul, 1983. Regulation of B cell growth and differentiation by soluble factors. Annu. Rev. Immunol. 1:307.
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© 1986 Springer-Verlag New York Inc.
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Jung, L.K.L., Hara, T., Fu, S.M. (1986). Detection and Functional Studies of IL-2 Receptors on Activated Human B Cells. In: Reinherz, E.L., Haynes, B.F., Nadler, L.M., Bernstien, I.D. (eds) Leukocyte Typing II. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4848-4_42
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DOI: https://doi.org/10.1007/978-1-4612-4848-4_42
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