Further Evidence that the Human Differentiation Antigen p24 Possesses Activity Associated with Protein Kinase
A fundamental premise underlying the study of differentiation is that the individual molecules on the surface of a cell, at a particular stage of maturation, have a functional role. This role may involve either the main-tenance of the individual cell or the regulation of its interaction with other cells and possibly the microenvironment. Significant clarification of the nature of the molecular composition of the cell surface during commitment to lineage and differentiation has been provided by investigations utilizing murine monoclonal antibodies (mAbs). The determination of the functional role played by these molecules has recently been addressed.
KeywordsAcute Lymphoblastic Leukemia Protein Kinase Activity Oncogene Product Avian Sarcoma Virus Calf Thymus Histone
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