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Drug Discovery and Development pp 227–256Cite as

Immunopharmacological Approaches to Drug Development

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Abstract

Knowledge of the immunologic system has increased tremendously over the last few decades. This has prompted the development of immunopharmacology, a new discipline that began to flourish in the 1970s, and that broadly addresses the effects of synthetic and natural products on the immune response (Mullen, 1979). The field of immunopharmacology encompasses the development of immunologically based assays and their research and clinical applications, the preparation and utilization of monoclonal antibodies as pharmacological tools or therapeutic agents, the pharmacological regulation of immune responsiveness, and immunotoxicology. The immunopharmacologist must conjoin fundamental pharmacology with modern immunology in an attempt to determine the biological and biochemical effects of synthetic and natural products on immune responsiveness, elucidate the mechanism(s) through which such effects are mediated, and evaluate the clinical potential of such agents.

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Authors
  1. Steven C. Gilman
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  2. Alan J. Lewis
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Editors and Affiliations

  1. Drug Discovery Administration, Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, New Jersey, USA

    Michael Williams

  2. Biomedical Research Department, Stuart Pharmaceuticals, ICI Americas Inc., Wilmington, Delaware, USA

    Jeffrey B. Malick

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Gilman, S.C., Lewis, A.J. (1987). Immunopharmacological Approaches to Drug Development. In: Williams, M., Malick, J.B. (eds) Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-4612-4828-6_9

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