The Proopiomelanocortin Genes

  • Michael Uhler
  • Edward Herbert
Part of the Molecular Biology and Biophysics book series (MBB)


Proopiomelanocortin (POMC) is the name given to the protein precursor for both ß-endorphin and adrenocorticotropin (ACTH). Although the proof of a common precursor for these important peptides was provided by chemical evidence (1–3), the elucidation of the exact structure of POMC and the prediction of other biologically important peptides in the same precursor was one of the first major demonstrations of the power of recombinant-DNA techniques (4). Because POMC is a member of a growing class of proteins (5) whose expression is regulated in a tissue-specific manner, it may serve as a model for studying the expression of other neuropeptide precursors. For these reasons, this chapter will review the determination of the structure of POMC and the studies concerning the regulation of expression of POMC.


Mouse Mammary Tumor Virus Intermediate Lobe POMC mRNA POMC Gene POMC mRNA Level 
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© The Humana Press Inc. 1987

Authors and Affiliations

  • Michael Uhler
  • Edward Herbert

There are no affiliations available

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