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Glycoprotein Hormone Genes

  • Chapter
Molecular Cloning of Hormone Genes

Part of the book series: Molecular Biology and Biophysics ((MBB))

Abstract

The glycoprotein hormone family is composed of four structurally related polypeptide hormones primarily produced by two specific endocrine tissues. Three such hormones, thyrotropin (TSH), lutropin (LH), and follitropin (FSH), are produced in the anterior pituitary gland in most mammals. A fourth hormone, chorionic gonadotropin (CG), is produced by the placenta in primates and possibly other mammals (1). In addition, it is well known that CG is produced by trophoblastic and nontrophoblastic tumors (2). In particular, malignant conditions of the lung, breast, gastrointestinal system, and central nervous system may produce CG or its components, which therefore serve as possible cancer markers (3–5). Also, recent reports suggest that pituitary glycoprotein hormones may be produced in the central nervous system (6,7).

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  1. William W. Chin
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Editors and Affiliations

  1. Laboratory of Molecular Endocrinology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, Massachusetts, USA

    Joel F. Habener

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Chin, W.W. (1987). Glycoprotein Hormone Genes. In: Habener, J.F. (eds) Molecular Cloning of Hormone Genes. Molecular Biology and Biophysics. Humana Press. https://doi.org/10.1007/978-1-4612-4824-8_7

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  • DOI: https://doi.org/10.1007/978-1-4612-4824-8_7

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