The Mouse as a Subject in the Study of Neural Mechanisms of Reward
Mice have several properties which make them ideal subjects for studying the effect of drugs on the reward process. They are compact, inexpensive, and available in strains which vary in number of dopamine receptors, opiate receptors, or sensitivity to alcohol. Mice can be lightly restrained by taping their tails to the floor thereby allowing electrical or chemical stimulation of the brain without the use of swivel connectors or commutators. Intravenous injections can be made through a lateral tail vein while the animal is restrained and is free to emit operants. This chapter describes these techniques and suggests some pitfalls to avoid.
KeywordsInbred Strain Opiate Receptor Pharmacology Biochemistry Lateral Tail Vein Electrical Brain Stimulation
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