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Hormone Resistance and Other Endocrine Paradoxes pp 204–230Cite as

States of Aldosterone Deficiency or Pseudodeficiency

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Part of the book series: Endocrinology and Metabolism ((EAM,volume 1))

Abstract

Sodium, chloride, potassium, and acid-base homeostasis in humans is dependent in part on the “mineralocorticoid activity” of steroid hormones secreted by the adrenal cortex and is reflected in the electrolyte and acid-base composition of the extracellular fluid and in the volume of the arterial blood. Aldosterone is the only adrenal steroid known to participate in the physiologic feedback regulation of electrolyte and volume homeostasis. Thus, primary or secondary disorders of the adrenal cortex that result in subnormal rates of aldosterone production are characterized by abnormalities in extracellular fluid volume, blood pressure, and electrolyte and acid-base composition. In addition, rare disorders in which signs and symptoms of aldosterone deficiency are present despite normal or elevated levels of aldosterone (so-called pseudohypoaldosteronism) also result in major alterations in mineral homeostasis. This chapter will review the pathophysiology and treatment of disorders due to aldosterone deficiency and pseudodeficiency in the context of our current understanding of the physiologic effects of mineralocorticoid hormones, summarized in Section I.

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Authors
  1. Morris Schambelan
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  2. Anthony Sebastian
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Editors and Affiliations

  1. University of Medicine and Dentistry of New Jersey, 07103, Newark, New Jersey, USA

    Margo Panush Cohen M.D., Ph.D. (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Institute for Metabolic Research, University City Science Center, 19104, Philadelphia, Pennsylvania, USA

    Margo Panush Cohen M.D., Ph.D. (Professor of Medicine, Director) (Professor of Medicine, Director)

  3. Wayne State University, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus of Physiology, Chairman Emeritus) (Professor Emeritus of Physiology, Chairman Emeritus)

  4. Department of Research, Sinai Hospital, Detroit, Michigan, 48202, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus of Physiology, Chairman Emeritus) (Professor Emeritus of Physiology, Chairman Emeritus)

  5. 2104 Rhine Road, 48033, West Bloomfield, Michigan, USA

    Piero P. Foà M.D., Sc.D. (Professor Emeritus of Physiology, Chairman Emeritus) (Professor Emeritus of Physiology, Chairman Emeritus)

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© 1987 Springer-Verlag New York Inc.

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Schambelan, M., Sebastian, A. (1987). States of Aldosterone Deficiency or Pseudodeficiency. In: Cohen, M.P., Foà, P.P. (eds) Hormone Resistance and Other Endocrine Paradoxes. Endocrinology and Metabolism, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4758-6_7

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  • DOI: https://doi.org/10.1007/978-1-4612-4758-6_7

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