Choriocarcinoma: Historical Notes

  • William B. Ober
Part of the Clinical Perspectives in Obstetrics and Gynecology book series (CPOG)


Although choriocarcinoma is quite distinctive both clinically and pathologically, it was not defined as an entity until 1889, nor was its histogenesis established until 1889; further, it was not fully accepted until 1903. In 1889 Max Sänger1 suggested that there was a special form of malignant tumor derived from the deciduas of pregnancy, which he called sarcoma uteri deciduocellulare. In 1895 Felix Marchand2 showed that these tumors were not derived from deciduas but from trophoblast (then called fetal epiblast). Marchand’s arguments were persuasive and quickly accepted on the Continent, but English obstetricians were reluctant to abandon the idea of a decidual origin and did not capitulate until John H. Teacher3 of Glasgow gave a memorable, well-illustrated paper to the Obstetrical Society of London in 1903.


Luteinizing Hormone Rheumatic Heart Disease Chorionic Villus Decidual Cell Hydatidiform Mole 
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© Springer-Verlag New York Inc. 1987

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  • William B. Ober

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