Capsaicin Sensitive Afferent Neurons Involved in Neuroendocrine Regulations

  • F. Lembeck
  • R. Amann
Conference paper


Capsaicin sensitive neurons have been shown to mediate various autonomic and neuroendocrine reflex responses [1]. Destruction of afferent peptidergic C fibres by treatment of neonatal rats with capsaicin [2] was used to investigate the function of these neurons in (A) stress induced ACTH secretion and (B) in the regulation of adrenaline release by insulin induced hypoglycaemia.


Cold Exposure Restraint Stress Insulin Induce Hypoglycaemia Capsaicin Treatment Hepatic Portal Vein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    . Lembeck (1985) Substance P and sensory neurones. In: Jordan CC, Oehme P (eds) Substance P: Metabolism and biological actions. Taylor and Francis: London, PhiladelphiaGoogle Scholar
  2. 2.
    Nagy JI (1982) Capsaicin: A chemical probe for sensory neuron mechanism. In: Iverson LL, Iverson SO, Snyder SH (eds) Handbook of psychopharmacology Vol 15. Plenum: New YorkGoogle Scholar
  3. 3.
    Jancsó G, Kiraly E, Jancsó-Gabór A (1977) Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature 270: 741–743PubMedCrossRefGoogle Scholar
  4. 4.
    Rivier C, Vale W (1985) Effects of corticotropin-releasing factor, neurohypophyseal peptides and catecholamines on pituitary function. Fed Proc 44:189–195PubMedGoogle Scholar
  5. 5.
    Tilders FJH, Berkenbosch F, Smelik PG (1982) Adrenergic mechanisms involved in the control of activity in the rat: pituitary-adrenal a β-adrenergic stimulatory mechanism. Endocinology 110:114–120CrossRefGoogle Scholar
  6. 6.
    Benzo CA (1983) The hypothalamus and blood glucose regulation. Life Sci 32: 2509–2515PubMedCrossRefGoogle Scholar
  7. 7.
    Barja F, Mathison R (1982) Adrenergic and peptidergic (substance P and vasoactive intestinal poypeptide) innervation of the rat portal vein. Blood Vessels 19: 263–272PubMedGoogle Scholar
  8. 8.
    Brown J (1962) Effects of 2-deoxyglucose on carbohydrate metabolism: Review of the literature and studies in the rat. Metabolism 11: 1098–1112PubMedGoogle Scholar
  9. 9.
    Mueller EE, Frohman LA, Cocchi D (1973) Drug control of hyperglycaemia and centrally administered 2-deoxy-D-glucose. Am J Physiol 2224: 1210–1217Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • F. Lembeck
    • 1
  • R. Amann
    • 1
  1. 1.Department of Exp. and Clin. PharmacologyUniversity of GrazGrazAustria

Personalised recommendations