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Release of Substance P from Isolated Guinea Pig Heart

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Substance P and Neurokinins

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Abstract

Several investigators have reported that substance P (SP)-immunoreactive nerve fibers are present in the heart and around coronary blood vessels and intracardiac ganglion cells [1–3]. Experiments with capsaicin have provided strong evidence that SP in the heart and coronary vasculature is in primary sensory nerves [4,5]. These SP-containing afferent nerves could be components of pathways mediating cardiac pain and cardiovascular reflexes. Their anatomical localization also supports the suggestion that SP may be released from peripheral sensory nerve endings and affect coronary blood flow and intracardiac ganglia [2,3]. Thusfar, pharmacological studies have shown that SP is a potent coronary vasodilator [1].

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References

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Authors and Affiliations

  1. Department of Pharmacology, College of Medicine, East Tennessee State University, Johnson City, Tennessee, 37614, USA

    D. B. Hoover

Authors
  1. D. B. Hoover
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Hoover, D.B. (1987). Release of Substance P from Isolated Guinea Pig Heart. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_69

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_69

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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