Influence of Anesthesia and Atropine on Plasma Extravasation Induced by Mammalian Tachykinins in the Rat

  • R. Kérouac
  • R. Couture
Conference paper


Until the recent discovery of two decapeptides, neurokinin A (NKA) and neurokinin B(NKB), substance P (SP) was the only tachykinin identified in mammalian tissues [1,2,3]. A common precursor for SP and NKA has been identified in bovine striatum [4] and the mRNA coding for these peptides has been found in sensory neurones [5] Using radiolabelled amino acids, co-synthesis of NKA and SP in rat sensory ganglia has been demonstrated [6]. It appears that SP and NKA are co-localized in certain primary afferent neurones while NKB is localized in interneurones or ascending pathways rather than in primary afferents [7]. The role of SP, released from the peripheral terminals of sensory C-fibres in the skin, has been studied in detail and there is convincing evidence for its involvement in antidromic vasodilatation and plasma protein extravasation [8]. It is likely, however, that a part of the neurogenic vascular responses that are now attributed to SP may, in fact, be mediated by other tachykinins.


Evans Blue Dorsal Skin Plasma Extravasation Tachykinin Receptor Plasma Protein Extravasation 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • R. Kérouac
    • 1
  • R. Couture
    • 1
  1. 1.Dept. of Physiology, CRSN, Faculty of MedicineUniversity of MontrealMontréalCanada

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