Influence of Anesthesia and Atropine on Plasma Extravasation Induced by Mammalian Tachykinins in the Rat
Until the recent discovery of two decapeptides, neurokinin A (NKA) and neurokinin B(NKB), substance P (SP) was the only tachykinin identified in mammalian tissues [1,2,3]. A common precursor for SP and NKA has been identified in bovine striatum  and the mRNA coding for these peptides has been found in sensory neurones  Using radiolabelled amino acids, co-synthesis of NKA and SP in rat sensory ganglia has been demonstrated . It appears that SP and NKA are co-localized in certain primary afferent neurones while NKB is localized in interneurones or ascending pathways rather than in primary afferents . The role of SP, released from the peripheral terminals of sensory C-fibres in the skin, has been studied in detail and there is convincing evidence for its involvement in antidromic vasodilatation and plasma protein extravasation . It is likely, however, that a part of the neurogenic vascular responses that are now attributed to SP may, in fact, be mediated by other tachykinins.
KeywordsPermeability Peri Acetylcholine Calcitonin Atropine
Unable to display preview. Download preview PDF.
- 1.Maggio JE, Sandberg BEB, Bradley CV, Iverson LL, Santikarn S, Williams DH, Hunter JC, Hanley MR (1983) A novel tachykinin in mammalian spinal cord. Ir J Med sci 152: (Suppl. 1) 45.Google Scholar
- 8.Lembeck F (1985) Substance P and sensory neurones. In: Jordan CC and Oehme P (eds) Substance P-metabo1ism and biological actions, by Taylor and Francis.Google Scholar
- 11.Couture R, Cuello AC, Henry JL (1985) Trigeminal antidromic vasodilatation and plasma extravasation in the rat: effects of acetylcholine antagonists and cholinesterase inhibitors. Br J Pharmac 84: 637–643.Google Scholar
- 14.Quirion R, Dam TV (1985) Multiple tachykinin receptors. In: Jordan CC and Oehme P (eds) Substance P-metabolism and biological actions, Taylor and Francis.Google Scholar