Advertisement

Influence of Anesthesia and Atropine on Plasma Extravasation Induced by Mammalian Tachykinins in the Rat

  • R. Kérouac
  • R. Couture
Conference paper

Abstract

Until the recent discovery of two decapeptides, neurokinin A (NKA) and neurokinin B(NKB), substance P (SP) was the only tachykinin identified in mammalian tissues [1,2,3]. A common precursor for SP and NKA has been identified in bovine striatum [4] and the mRNA coding for these peptides has been found in sensory neurones [5] Using radiolabelled amino acids, co-synthesis of NKA and SP in rat sensory ganglia has been demonstrated [6]. It appears that SP and NKA are co-localized in certain primary afferent neurones while NKB is localized in interneurones or ascending pathways rather than in primary afferents [7]. The role of SP, released from the peripheral terminals of sensory C-fibres in the skin, has been studied in detail and there is convincing evidence for its involvement in antidromic vasodilatation and plasma protein extravasation [8]. It is likely, however, that a part of the neurogenic vascular responses that are now attributed to SP may, in fact, be mediated by other tachykinins.

Keywords

Evans Blue Dorsal Skin Plasma Extravasation Tachykinin Receptor Plasma Protein Extravasation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Maggio JE, Sandberg BEB, Bradley CV, Iverson LL, Santikarn S, Williams DH, Hunter JC, Hanley MR (1983) A novel tachykinin in mammalian spinal cord. Ir J Med sci 152: (Suppl. 1) 45.Google Scholar
  2. 2.
    Kimura S, Okada M, Sugita Y, Kanagawa I, Munekata E (1983) Novel neuro-peptides, neurokinin α and β, isolated from porcine spinal cord. Proc Jpn Acad 59: 101–04.CrossRefGoogle Scholar
  3. 3.
    Kangawa K, Minamino N, Fukuda A, Matsuo H (1983) Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord. Biochem Biophys Res Commun 114: 533–540.PubMedCrossRefGoogle Scholar
  4. 4.
    Nawa H, Hirose T, Takashima H, Inayama S, Nakanishi S (1983) Nucleotide sequences of cloned cDNAs for two types of bovine substance P precursor. Nature 306: 32–36.PubMedCrossRefGoogle Scholar
  5. 5.
    Nawa H, Kolani H, Nakanishi S (1984) Tissue-specific generation of two preprotachykinins mRNAs from one gene by alternative RNA slicing. Nature 312: 729–734.PubMedCrossRefGoogle Scholar
  6. 6.
    Harmar AJ, Keen P (1984) Rat sensory ganglia incorporate radio1abe11ed amino acids into substance K (neurokinin ex ) in vitro. Neurosc Letters 51: 387–391.CrossRefGoogle Scholar
  7. 7.
    Ogawa T, Kanazawa I, Kimura S (1985) Regional distribution of substance P, neurokinin α and neurokinin β in rat spinal cord, nerve roots and dorsal root ganglia: and the effects of dorsal root section or spinal transection. Brain Res 359: 152–157.PubMedCrossRefGoogle Scholar
  8. 8.
    Lembeck F (1985) Substance P and sensory neurones. In: Jordan CC and Oehme P (eds) Substance P-metabo1ism and biological actions, by Taylor and Francis.Google Scholar
  9. 9.
    Regoli D, Mizrahi J, D’Orléans-Juste P, Dion S, Drapeau G, Escher E (1985) Substance P antagonists showing some selectivity for different receptor types. Eur J Pharmac 109: 121–125.CrossRefGoogle Scholar
  10. 10.
    Couture R, Cuello AC (1984) Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat. J Physiol 346: 273–285.PubMedGoogle Scholar
  11. 11.
    Couture R, Cuello AC, Henry JL (1985) Trigeminal antidromic vasodilatation and plasma extravasation in the rat: effects of acetylcholine antagonists and cholinesterase inhibitors. Br J Pharmac 84: 637–643.Google Scholar
  12. 12.
    Couture R, Cuello AC, Henry JL (1985) Trigeminal antidromic vasodilatation and plasma extravasation in the rat: effects of sensory, autonomic and motor denervation. Brain Res 346: 108–114.PubMedCrossRefGoogle Scholar
  13. 13.
    Gamse R, Saria A (1985) Potentiation of tachykinin-induced plasma protein extravasation by calcitonin gene-related peptide. Eur J Pharmaco1 114: 61–66.CrossRefGoogle Scholar
  14. 14.
    Quirion R, Dam TV (1985) Multiple tachykinin receptors. In: Jordan CC and Oehme P (eds) Substance P-metabolism and biological actions, Taylor and Francis.Google Scholar
  15. 15.
    Regoli D (1985) Peptide antagonists. Trends in Pharmacol Sci 62: (12): 481–484.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • R. Kérouac
    • 1
  • R. Couture
    • 1
  1. 1.Dept. of Physiology, CRSN, Faculty of MedicineUniversity of MontrealMontréalCanada

Personalised recommendations