Effects of Substance P on Blood Flow of the Dental Pulp in Dogs

  • S. Kim
  • J. Dorscher-Kim
Conference paper


Substance P (SP) is a known potent vasodilator (1, 2, 3). Olgart and his coworkers found SP-like immunoreactivity (SPLI) in nerves of the cat pulp suggesting the presence of SP (4). In addition, Gazelius and Olgart (5) demonstrated that electrical stimulation of the inferior alveolar nerve in cats caused a rapid increase in pulp blood flow which was followed by a prolonged reduction in pulp blood flow. The increase is thought to be mediated by SP released at the pulpal sensory nerve endings (6). However, administration of synthetic SP failed to increase pulp blood flow in cats; only when the vascular tone was elevated by electrical stimulation of the sympathetic nerve did the SP administration cause a pulp blood flow increase (5).


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Lofstrom B, Pernow Band Wahren J (1965) Vasodilating action of substance P in the human forearme. Acta Physiol Scand 63:311–324.CrossRefGoogle Scholar
  2. [2]
    Fredholm BB, Oberg B and Roselle S (1970) Effects of Vasoactive drugs on circulation in canine sUbcutaneous adipose tissue. Acta Physiol Scand 79: 564–574.PubMedCrossRefGoogle Scholar
  3. [3]
    Pernow B and Roselle S (1975) Effect of substance P on blood flow in canine adipose tissue and skeletal muscle. Acta Physiol Scand 93:139–145.PubMedCrossRefGoogle Scholar
  4. [4]
    Olgart L, Hokfelt T, Nilsson G and Pernow B (1977) Localization of substance P-like immunoreactivity in nerves in the tooth pulp. Pain 4:153–159.PubMedCrossRefGoogle Scholar
  5. [5]
    Gazelius B Olgart L (1980) Vasodilatation in the dental pulp produced by electrical stimulation of the inferior alveolar nerve in the cat. Acta Physiol Scand 108:181–186.PubMedCrossRefGoogle Scholar
  6. [6]
    Gazelius B, Brodin E, Olgart L and Panapoulos P (1981) Evidence that substance P is a mediator of antidromic vasodilation using somatostatin as a release inhibitor. Acta Physiol Scand 113:155–159.PubMedCrossRefGoogle Scholar
  7. [7]
    Brodin E, Gazelius B, Olgart L and Nilsson G (1981) Tissue concentration and release of substance P-like immunoreactivity in the dental pulp. Acta Physiol Scand 111:141–149.PubMedCrossRefGoogle Scholar
  8. [8]
    Tonder K (1976) Effect of vasodilating drugs on external carotid and pulpal blood flow in dogs: “Stealing of dental perfusion pressure”. Acta Physiol Scand 97:75–87.PubMedCrossRefGoogle Scholar
  9. [9]
    Meyer MW (1970) Distribution of cardiac output to the oral tissues in dog. J Dent Res 49:787–794.PubMedCrossRefGoogle Scholar
  10. [10]
    Kim S (1985) Regulation of pulpal blood flow. J Dent Res 64:(Spec Iss) 590-6.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • S. Kim
    • 1
  • J. Dorscher-Kim
    • 1
  1. 1.Lab. of Oral Physiology and Department of EndodonticsColumbia University, School of Dental and Oral SurgeryNew YorkUSA

Personalised recommendations