Characterization of Spinal Actions of Ten Substance P Analogs

  • R. Couture
  • A. Gupta
  • R. Kérouac
  • E. Escher
  • D. Regoli
Conference paper

Abstract

On the basis of data obtained in smooth muscles [1] it was assumed that substance P (SP) analogues containing D-amino acids will antagonise the spinal actions of tachykinins. It was however rapidly realised that SP antagonists exert direct effects on the rat spinal cord. In fact, undeca or C-terminal octapeptide analogues of SP containing D-Trp in positions 7 and 9 or 7,9 and 10 cause an initial increase of the blood pressure followed by a long lasting fall to levels below 80 mmHg within 20–30 min when applied intrathecally (i.th.). In a number of experiments, the hypotension was large enough to cause death of the animal [2, 3, 4].

Keywords

Morphine Histamine Noradrenaline Propranolol Cimetidine 

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References

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • R. Couture
    • 1
  • A. Gupta
    • 1
  • R. Kérouac
    • 1
  • E. Escher
    • 1
    • 2
  • D. Regoli
    • 1
    • 2
  1. 1.Dept. of Physiology, Faculty of MedicineUniversity of MontrealMontréalCanada
  2. 2.Dept. of Pharmacology, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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