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Tachykinin Activation of Muscarinic Inhibition in Canine Small Intestine is Substance P in Nature

  • J. E. T. Fox
  • T. J. McDonald
  • L. Alford
  • F. Kostolanska
Conference paper

Abstract

Substance P, when injected intra-arterially into the small intestine of the anesthetized dog during phasic activity, produces a dose dependant inhibition of the phasic activity. This inhibitory response was abolished by elimination of field stimulated activity by intra-arterial tetrodotoxin, but reduced by atropine treatment (on activity induced by intra-arterial motilin). This suggested that Substance P acted by releasing several inhibitory transmitters, one of which was probably acetylcholine acting on inhibitory autoreceptors on cholinergic nerves [1]. The identity of the other transmitter/ transmitters is unknown.

Keywords

Cholinergic Nerve Krebs Ringer Bicarbonate Atropine Treatment Potency Sequence Muscarinic Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • J. E. T. Fox
    • 1
  • T. J. McDonald
    • 2
  • L. Alford
    • 1
  • F. Kostolanska
    • 1
  1. 1.Program for Study of Smooth Muscle FunctionMcMaster UniversityLondonCanada
  2. 2.Hamilton and Dept. of MedicineUniversity of Western OntarioLondonCanada

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