Multiple Neurokinin Receptors in the Guinea Pig Ileum

  • H. I. Jacoby
  • I. Lopez
  • D. Wright
  • J. L. Vaught
Conference paper

Abstract

We have recently synthesized a neurokinin B analog, [D-Pro2,D-Trp6,8,Nlel0]NB (DPDTNLE-NB), which shows selective competitive antagonism of neurokinin B with minimal agonist activity [1]. Our objective in this study was to use this antagonist and two substance P analog antagonists (Spantide and DPDT-SP) to systematically investigate neurokinin receptors in the guinea pig ileum.

Keywords

Dioxide DMSO Acetylcholine Atropine 

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References

  1. 1.
    Wright DE, Jacoby HI, Scott RW, Vaught JL (1985) Tachykinin antagonists and multiple receptors, Peptides. Proc. of Ninth Am. Peptide Symposium - Pierce Chemical Co., Rockford, IL 651–654.Google Scholar
  2. 2.
    Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Brit. J. Pharmacol. 14:48–58.PubMedGoogle Scholar
  3. 3.
    Tallarida RJ, Jacob LS (1979) The dose response relation in pharmacology. Springer-Verlag, NY 62–65.Google Scholar
  4. 4.
    Buck SH, Burcher E (1986) The tachykinins: a family of pept1des with a brood of “receptors”. T.I.P.S. 7:65–72.Google Scholar
  5. 5.
    Laufer R, Wormser U, Friedman ZY, Gilan C, Chorev M, Selinger Z (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc. Natl. Acad. 82:444–448.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • H. I. Jacoby
    • 1
  • I. Lopez
    • 1
  • D. Wright
    • 1
  • J. L. Vaught
    • 1
  1. 1.Departments of Biological and Chemical ResearchMcNeil PharmaceuticalSpring HouseUSA

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