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Multiple Neurokinin Receptors in the Guinea Pig Ileum

  • H. I. Jacoby
  • I. Lopez
  • D. Wright
  • J. L. Vaught
Conference paper

Abstract

We have recently synthesized a neurokinin B analog, [D-Pro2,D-Trp6,8,Nlel0]NB (DPDTNLE-NB), which shows selective competitive antagonism of neurokinin B with minimal agonist activity [1]. Our objective in this study was to use this antagonist and two substance P analog antagonists (Spantide and DPDT-SP) to systematically investigate neurokinin receptors in the guinea pig ileum.

Keywords

Competitive Antagonist Kinin Receptor Neurokinin Receptor Concentration Response Curve Intramural Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Laufer R, Wormser U, Friedman ZY, Gilan C, Chorev M, Selinger Z (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc. Natl. Acad. 82:444–448.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • H. I. Jacoby
    • 1
  • I. Lopez
    • 1
  • D. Wright
    • 1
  • J. L. Vaught
    • 1
  1. 1.Departments of Biological and Chemical ResearchMcNeil PharmaceuticalSpring HouseUSA

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