Multiple Neurokinin Receptors in the Guinea Pig Ileum
We have recently synthesized a neurokinin B analog, [D-Pro2,D-Trp6,8,Nlel0]NB (DPDTNLE-NB), which shows selective competitive antagonism of neurokinin B with minimal agonist activity . Our objective in this study was to use this antagonist and two substance P analog antagonists (Spantide and DPDT-SP) to systematically investigate neurokinin receptors in the guinea pig ileum.
KeywordsDioxide DMSO Acetylcholine Atropine
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