Abstract
There are many instances where these spasmogens applied to smooth muscle preparations have both a direct action on the smooth muscle cells, as well as an indirect action through release of some other mediator [1] . It is obviously of importance when studying a system where an indirect action is apparent, to identify the mediator involved, since analysis of mixed responses is not otherwise possible in receptor classification or mechanistic studies.
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References
Couture R, Regoli D (1982) Minireview: smooth muscle pharmacology of substance P. Pharmacology 24:1–25
Holzer P, Lembeck F (1980) Neurally mediated contraction ileal longitudinal muscle by substance P. Neurosci Lett 17:101–105
Yau WM, Yauther ML (1982) Direct evidence for a release of acetylcholine from the myenteric plexus of guinea-pig small intestine by substance P. Europ J Pharmac 81:665–668
Fosbraey P, Featherstone RL, Morton IKM (1984) Comparison of potency of subtance P and related peptides on [3H]-acetylcholine release, and contractile actions in the guinea-pig ileum. N S Arch Pharmac 326:111–115
Featherstone RL, Fosbraey P, Morton IKM (1986) A comparison of the effects of three substance P antagonists on tachykinin- stimulated [3H]-acetylcholine release in guinea-pig ileum. Brit J Pharmac 87:73–78
Burleigh DE, Trout SJ (1985) Substance P contractions of guinea-pig taenia caeci by a direct action on smooth muscle. Brit J Pharmac 84:165P
Bailey SJ, Featherstone RL, Jordon CC, Morton IKM (1986) An examination of the pharmacology of two substance P antagonists and the evidence for tachykinin receptor subtypes. Brit J Pharmac 87:79–85
Lee C, Iverson L, Hanley M, Sandberg EB (1982) The possible existence of multiple receptors for substance P. N S Arch Pharmacol 318:281–287.
Bailey SJ (1984) A pharmacological study of the tachykinin receptors present in the rat colon: comparison with those in the guinea-pig ileum. PhD. Thesis, University of London.
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© 1987 Springer-Verlag New York Inc.
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Morton, I.K.M., Hall, J.M. (1987). Neurokinin Receptors in Guinea-Pig Intestinal Muscle. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_46
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DOI: https://doi.org/10.1007/978-1-4612-4672-5_46
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