Abstract
In smooth muscle, a rise in free intracellular calcium is considered to be of primary importance in determining the degree of actin-myosin interaction, and resultant contraction, although other processes may also operate. Contraction due to hormone-receptor interaction utilises the two main sources of calcium, namely extracellular calcium and stored intracellular calcium, which can be made available by some combination of three mechanisms: (1) namely (a) entry of extracellular calcium via voltage-operated channels (VOCs). (b) Entry of extracellular calcium via receptor-operated channels (ROCs). (c) Release of intracellular calcium from storage sites such as the sarcoplasmic reticulum (SR) within the cell. The extent and efficiency of different agonists in using these three calcium translocation mechanisms varies depending both on the particular type of smooth muscle concerned, and also the agonist-receptor system mediating the response.
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References
Bolton TB (1979) Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59:606–718.
Adams PR, Brown DD, Jones SW (1983) Substance P inhibits the M-current in bullfrog sympathetic neurons. Er J Pharmac 79:330–333.
Sims SM, Singer JJ, Walch JV (1985) Cholinergic agonists suppress a potassium current in freshly dissociated smooth muscle cells of the toad. J Physiol 367:503–529.
Holzer P, Petsche U (1983) On the mechanism of contraction and desensitization induced by substance P in the intestinal muscle of the guinea-pig. J Physiol 342:549–568.
Hall JM, Morton IKM (1986) The effect of potassium channel blockers on thee-responses to substance P and other spasmogens in longitudinal smooth muscle from the guines-pig ileum. J Physiol 371:260P.
Jenkinson DH, Morton IKM (1967) The effect of noradrenaline on the permeability of depolarised intestinal smooth muscle. J Physiol 188:373–386.
Hall JM, Morton IKM (1986) Different receptor systems in intestinal smooth muscle vary in their ability to trans locate calcium. Brit J Pharmac 87: 206P.
Hall JM, McCabe DV, Morton IKM (1986) A comparison of receptor-effector coupling of histamine and analogues with that of carbachol in the guinea-pig taenia caeci. Brit Pharmac Soc Mtg, Amsterdam (july).
Watson SP, Downes CP (1983) Substance P-induced hydrolysis of inositol phospholipid in guinea-pig ileum and rat hypothalamus. Europ J Pharmac 93: 245–253.
Holzer P, Lippe I Th (1985) Substance P action on phosphoinositols in guinea-pig intestinal muscle: a possible transduction mechanism? N. S. Arch Pharmac 329:50–55.
Watson SP (1984) Minireview: Are the proposed substance P receptor subtypes, substance Preceptors? Life Sci 35:797–808.
Fosbraey P, Newman CM, Morton IKM (1985) The effect of Pertussis toxin p1·etreatment of μ- and - opioid modulation of neurotrans mitter output. Brit J Pharmac 86:705P.
Hall JM & Morton IKM (1986) Is inhibitory regulation of adenylate cyclase involved in the action of spasmogens on intestinal smooth muscle? Brit J Pharmac 86:73lP.
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© 1987 Springer-Verlag New York Inc.
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Hall, J.M., Morton, I.K.M. (1987). Neurokinin Receptor Mechanisms in Smooth Muscle. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_45
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DOI: https://doi.org/10.1007/978-1-4612-4672-5_45
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