Neurokinin Fragments and Analogues as Selective Activators of Receptors
The characterization of receptors for neurokininsis pursued today by using primarily agonists and by applying the first criterion recommended by Schild  in 1973. As shown by the tracing of a precedent paper (D’Orléans-Juste et al. ), the effects of neurokinins on isolated vessels, (which represent the most selective pharmacological preparations for neurokinins) are rather persistent and stable: therefore these tissues cannot be used for desensitization experiments. Antagonists for neurokinins are still in an early phase of development and may be used for characterization of one of the three receptor types on which neurokinin act, namely the NK-P, but not for the others .
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