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Neurokinin Fragments and Analogues as Selective Activators of Receptors

  • S. Dion
  • P. D’Orléans-Juste
  • N. E. Rhaleb
  • G. Drapeau
  • P. Rovero
  • D. Regoli
Conference paper

Abstract

The characterization of receptors for neurokininsis pursued today by using primarily agonists and by applying the first criterion recommended by Schild [7] in 1973. As shown by the tracing of a precedent paper (D’Orléans-Juste et al. [2]), the effects of neurokinins on isolated vessels, (which represent the most selective pharmacological preparations for neurokinins) are rather persistent and stable: therefore these tissues cannot be used for desensitization experiments. Antagonists for neurokinins are still in an early phase of development and may be used for characterization of one of the three receptor types on which neurokinin act, namely the NK-P, but not for the others [3].

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References

  1. 1.
    Schild HO (1973) Receptor classification with special reference to beta adrenergic receptors. In: Rang HP (ed) Drug receptors pp. 29–36,Baltimore, University Park PressGoogle Scholar
  2. 2.
    D’Orléans-Juste P, Dion S, Rhaleb NE, Drapeau G, Regoli D (1986) Isolated arterial and venous vessels as selective pharmacological preparations for neurokinins. This issue pp.Google Scholar
  3. 3.
    Regoli D, Drapeau G, Dion S, D’Orléans-Juste P (1986) Recent developments in neurokinin pharmacology. Life Sci (in press)Google Scholar
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    Drapeau G, Rovero P, D’Orléans-Juste P, Dion S, Rhaleb NE, Regoli D (1986) Mammalian neurokinins: structure-activity study of the N- and C-terminals. This issue pp.Google Scholar
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    Regoli D, Drapeau G, Dion S, D’Orléans-Juste P (1986) Receptors for neurokinins in peripheral organs. This issue ppGoogle Scholar
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    Ariens EJ (1964) Molecular Pharmacology. London Academic PressGoogle Scholar
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    Schild HO (1947) pA, a new scale for the measurement of drug antagonism. Br J Pharmacol 2:189–206Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • S. Dion
    • 1
  • P. D’Orléans-Juste
    • 1
  • N. E. Rhaleb
    • 1
  • G. Drapeau
    • 1
  • P. Rovero
    • 1
  • D. Regoli
    • 1
  1. 1.Department of Pharmacology, Medical SchoolUniversity of SherbrookeSherbrookeCanada

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