Advertisement

[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B: Pharmacological Profile of a Novel Neurokinin Antagonist

  • J. L. Vaught
  • R. Scott
  • D. Wright
  • H. Jacoby
Conference paper

Abstract

Until recently, substance P was the only member of the neurokinin family of peptides of mammalian origin. Thus, sub-classification of neurokinin receptors as well as synthetic efforts to create a neurokinin antagonist utilized substance P as the prototypic peptide [1]. Within the last three years, however, two additional mammalian peptides have been isolated. sequenced, purified and shown to have biological activities characteristic of the neurokinin family: neurokinin A and neurokinin B [2–4].

Keywords

Neurokinin Receptor Synthetic Effort Control Reaction Time Neurokinin Antagonist American Peptide Symposium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Regoli D, Escher E, Mizrahi J (1984) Substance P:Structure-activity stUdies and the development of antagonists. Pharmacology 28:301–320.PubMedCrossRefGoogle Scholar
  2. 2.
    Kangawa K, Minamino N, Fukuda A, Matsuo H (1983) Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord. Biochem. Biophys. Res. Commun. 114:533–540.PubMedCrossRefGoogle Scholar
  3. 3.
    Kimura S, Okada M, Sugita Y, Kanazawa I, Munekata E (1983) Novel neuropeptides, neurokinin a and i3 isolated from porcine spinal cord. Proc. Jap. Acad. (Sci. Ser. 13) 59: 101–111.CrossRefGoogle Scholar
  4. 4.
    Vaught JL, Post LJ, Jacoby HI, Wright D (1984) Tachykinin-like central activity of neuromedin K in mice. Eur. J. Pharmacol. 103:355–357.PubMedCrossRefGoogle Scholar
  5. 5.
    Arunlakshana O, Schild HO (1959) Some quantitative uses of drug antagonists. Brit. J. Pharmacol. 14:48–58.PubMedGoogle Scholar
  6. 6.
    Hylden JLK, Wilcox GL (1980) Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. 67:313–315.PubMedCrossRefGoogle Scholar
  7. 7.
    Wright DE, Jacoby HI, Scott RW, Vaught JL (1985) Peptides. Proceedings of the Ninth American Peptide Symposium, Eds. C.M. Deber et al. 651–654, Pierce Chemical Co., Rockford, IL.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • J. L. Vaught
    • 1
  • R. Scott
    • 1
  • D. Wright
    • 1
  • H. Jacoby
    • 1
  1. 1.Departments of Biological and Chemical ResearchMcNeil PharmaceuticalSpring HouseUSA

Personalised recommendations